CASE REPORT article
Front. Dent. Med.
Sec. Regenerative Dentistry
Volume 6 - 2025 | doi: 10.3389/fdmed.2025.1664854
This article is part of the Research TopicAdvances in Multi-Omics and Imaging for Precision DentistryView all articles
Etiology of pulp necrosis as a predictor of success in regenerative endodontics: A case report and bioinformatic analysis
Provisionally accepted
- University of Chile, Santiago, Chile
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Regenerative endodontics (RE) is a biologically based procedure designed to replace damaged dental structures, including dentin and root structures, and cells of the pulp-dentin complex. It is the first-line treatment for patients with immature permanent teeth (IPT) that have lost vitality due to dentoalveolar trauma (DAT), caries, or developmental anomalies such as dens evaginatus (DE). Beyond resolving clinical signs and symptoms, RE allows for continued root development, substantially improving the long-term prognosis of these cases. Here, we present a clinical case of a 12-year-old female patient who, as a result of dentoalveolar trauma, exhibits asymptomatic apical periodontitis of tooth 1.1 and chronic apical abscess of tooth 2.1 in IPT. Both teeth were treated with regenerative endodontics, achieving successful RE in tooth 2.1 and inducing apical closure with Biodentine in tooth 1.1. In addition, we conducted a bioinformatic analysis to identify key genes associated with the success of post-trauma RE, providing a more complete and mechanistic understanding of the factors determining treatment success. In conclusion, the success of RE procedures in IPT may be conditioned by the type of DAT suffered by the tooth. Moreover, incorporating bioinformatic analysis introduces an innovative approach to unravel the molecular mechanisms involved in post-trauma dental regeneration.
Keywords: dental trauma, Regenerative endocontics, Immature permanent teeth, Bioinfor matics, TNF
Received: 12 Jul 2025; Accepted: 14 Oct 2025.
Copyright: © 2025 González, Alcota, Torres, Ledezma, Mercado and Paredes. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Fermín E González, fgonzalez@uchile.cl
Marcela Alcota, malcota@u.uchile.cl
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