Frontiers in Drug Discovery

Brief Research Report

Published on 03 Aug 2023

Novel mesothelin antibodies enable crystallography of the intact mesothelin ectodomain and engineering of potent, T cell-engaging bispecific therapeutics

in Anti-Cancer Drugs

Ida Lin
Peter B. Rupert
Kristina Pilat
Raymond O. Ruff
Della J. Friend
Man Kid Chan
Midori Clarke
Benjamin G. Hoffstrom
Jane Carter
Soheil Meshinchi

Frontiers in Drug Discovery

doi 10.3389/fddsv.2023.1216516

5,594 views
4 citations

Review

Published on 25 Jul 2023

The importance of good practices and false hits for QSAR-driven virtual screening real application: a SARS-CoV-2 main protease (Mpro) case study

in In silico Methods and Artificial Intelligence for Drug Discovery

Mateus Sá Magalhães Serafim
Simone Queiroz Pantaleão
Elany Barbosa da Silva
James H. McKerrow
Anthony J. O’Donoghue
Bruno Eduardo Fernandes Mota
Kathia Maria Honorio
Vinícius Gonçalves Maltarollo

Frontiers in Drug Discovery

doi 10.3389/fddsv.2023.1237655

3,931 views
7 citations

Original Research

Published on 20 Jul 2023

9-PAHSA displays a weak anti-inflammatory potential mediated by specific antagonism of chemokine G protein-coupled receptors

in Anti-inflammatory and Immunomodulating Agents

Paulus Wohlfart
Mounir Chehtane
Ernesto Luna
Riyaz Mehta
Marcus Korn
Anish Konkar
Uwe Schwahn
Stefan Petry
Norbert Tennagels
Maximilian Bielohuby

Frontiers in Drug Discovery

doi 10.3389/fddsv.2023.1138461

3,615 views

Review

Published on 13 Jul 2023

Targeting proteases and proteolytic processing of unusual N-terminal extensions of Plasmodium proteins: parasite peculiarity

in Anti-Infective Agents

Ankita Tehlan
Abhik Saha
Suman Kumar Dhar

Frontiers in Drug Discovery

doi 10.3389/fddsv.2023.1223140

2,294 views
1 citation

Mini Review

Published on 12 Jul 2023

FAIR data management: what does it mean for drug discovery?

in Technologies and Strategies to Enable Drug Discovery

Yojana Gadiya
Vassilios Ioannidis
David Henderson
Philip Gribbon
Philippe Rocca-Serra
Venkata Satagopam
Susanna-Assunta Sansone
Wei Gu

Frontiers in Drug Discovery

doi 10.3389/fddsv.2023.1226727

3,479 views
8 citations

Original Research

Published on 07 Jul 2023

The tumor suppressor 5A2, a synthetic miR-7-5p mimic, targets oncogenic and metabolic pathways, as revealed by transcriptome-wide analysis

in Anti-Cancer Drugs

Marion T. J. van den Bosch
Bryony J. Telford
Sanaz Yahyanejad
Thijs de Gunst
Harm C. den Boer
Rogier M. Vos
Chantal L. Duurland
Rianne Biemans
Ludwig J. Dubois
Laurens A. H. van Pinxteren

Frontiers in Drug Discovery

doi 10.3389/fddsv.2023.1181637

2,051 views

Review

Published on 21 Jun 2023

Yin-yang in drug discovery: rethinking de novo design and development of predictive models

in In silico Methods and Artificial Intelligence for Drug Discovery

Ana L. Chávez-Hernández
Edgar López-López
José L. Medina-Franco

Frontiers in Drug Discovery

doi 10.3389/fddsv.2023.1222655

6,477 views
5 citations

Original Research

Published on 15 Jun 2023

MMV006087 is a potent Malaria Box compound against Plasmodium falciparum clinical parasites

in Anti-Infective Agents

Jersley D. Chirawurah
Bridget Adikah
Felix Ansah
Elizabeth Laryea-Akrong
Harry Danwonno
Collins M. Morang’a
Daniel Dosoo
Lucas Amenga-Etego
Gordon A. Awandare
Yaw Aniweh

Frontiers in Drug Discovery

doi 10.3389/fddsv.2023.1190471

2,867 views
1 citation

Review

Published on 01 Jun 2023

Lessons that can be learned from the SARS-CoV-2 pandemic and their impact on the prophylaxis and treatment development for neglected tropical arboviruses

in Anti-Infective Agents

Danilo Rosa-Nunes
Danilo B. M. Lucchi
Robert Andreata-Santos
Luiz Mario R. Janini
Carla Torres Braconi

Frontiers in Drug Discovery

doi 10.3389/fddsv.2023.1176768

5,054 views

Mini Review

Published on 24 May 2023

Drug discovery and development: introduction to the general public and patient groups

in Technologies and Strategies to Enable Drug Discovery

Natesh Singh
Philippe Vayer
Shivalika Tanwar
Jean-Luc Poyet
Katya Tsaioun
Bruno O. Villoutreix

Frontiers in Drug Discovery

doi 10.3389/fddsv.2023.1201419

189,981 views
142 citations

Review

Published on 10 May 2023

The critical role of mode of action studies in kinetoplastid drug discovery

in Anti-Infective Agents

Alan H. Fairlamb
Susan Wyllie

Frontiers in Drug Discovery

doi 10.3389/fddsv.2023.1185679

3,871 views
8 citations

Original Research

Published on 09 May 2023

Generation of a potent anti-PD-L1-CD47 bispecific antibody with a strong therapeutic and safety profile for cancer immunotherapy

in Anti-Cancer Drugs

Irene Tang
Lauren Schwimmer
Shenda Gu
Wei Wei Prior
Hieu Van Tran
Allan Chan
Anna McClain
Christopher C. Fraser
Chunyan Sun
Meimei Si

Frontiers in Drug Discovery

doi 10.3389/fddsv.2023.1182146

5,206 views
1 citation

Editorial

Published on 27 Feb 2023

Editorial: Development/repurposing of drugs to tackle the multiple variants of SARS-CoV-2

in Anti-Infective Agents

Dinorah Gambino

Frontiers in Drug Discovery

doi 10.3389/fddsv.2023.1157688

1,366 views
2 citations

Brief Research Report

Published on 21 Feb 2023

Numaswitch, a biochemical platform for the efficient production of disulfide-rich pepteins

in Neurological Drugs

Bach-Ngan Nguyen
Florian Tieves
Florian G. Neusius
Hansjörg Götzke
Lutz Schmitt
Christian Schwarz

Frontiers in Drug Discovery

doi 10.3389/fddsv.2023.1082058

3,909 views
1 citation

Original Research

Published on 10 Feb 2023

HMM-based profiling identifies the binding to divalent cations and nucleotides as common denominators of suramin targets

in Anti-Infective Agents

Dennis A. Hauser
Pascal Mäser

Frontiers in Drug Discovery

doi 10.3389/fddsv.2023.1112992

2,086 views

Original Research

Published on 08 Feb 2023

Identification of novel genetic variants, including PIM1 and LINC01491, with ICD-10 based diagnosis of pulmonary arterial hypertension in the UK Biobank cohort

in Cardiovascular and Hematologic Drugs

Alex Pu
Gautam Ramani
Yi-Ju Chen
James A. Perry
Charles C. Hong

Frontiers in Drug Discovery

doi 10.3389/fddsv.2023.1127736

4,728 views
6 citations