CLINICAL TRIAL article
Front. Gastroenterol.
Sec. Hepatology
Relationship Between Partial Splenic Artery Embolization and Overt Hepatic Encephalopathy after Transjugular Intrahepatic Portosystemic Shunt
Yuxing Feng 1,2,3,4,5
xin XIONG 3
long GAO 3
Jinyu Li 3
duiping FENG 3
1. Student Competitions, Stockholm, Sweden
2. shanxi medical universit, tai yuan, China
3. shanxi medical universit, taiyuan in shanxi, China
4. shanxi medical universit, taiyuan Province, China
5. shanxi medical universit, shi jia zhuang, China
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Abstract
Purpose: This study aimed to investigate the relationship between the incidence of overt hepatic encephalopathy (OHE) and the combination of transjugular intrahepatic portosystemic shunt (TIPS) and partial splenic artery embolization (PSE). Methods: Patients with liver cirrhosis who underwent TIPS for the first time between June 2019 and June 2022 at the First Hospital of Shanxi Medical University were included. The patients were divided into an observation group (n=28) and a control group (n=55) in a 1:2 propensity score matching manner. Patients in the observation group received PSE before or after TIPS. The incidence of OHE was observed in both groups within one year. Results: The one-year cumulative incidence of OHE in the observation group was significantly lower than that in the control group (17.9% vs. 40.0%, P=0.042). There was no significant change in serum Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST), and Prothrombin Time (PT) levels before and after surgery in both groups (P>0.05), but the Total Bilirubin (TB) level in the control group increased significantly (P<0.05). The Red Blood Cell (RBC) and Platelet (PLT) levels in the observation group were significantly higher than those before surgery (P<0.05). Multivariate logistic regression analysis showed that the risk of OHE in the control group was 4.425 times that in the observation group (OR=4.425, P=0.025), and advanced age was a risk factor for OHE after TIPS (OR=1.102, P=0.001). Conclusion: Compared with TIPS alone, the combination of TIPS and PSE can better control the incidence and severity of OHE after surgery, and can improve the peripheral blood profile and liver function in the mid-to-long term after surgery in patients with liver cirrhosis, providing new ideas for prevenetive OHE after TIPS.
Summary
Keywords
cirrhosis, Hypersplenism, Overt hepatic encephalopathy, partial splenic artery embolization, Transjugular intrahepatic portosystemic shunt
Received
17 May 2025
Accepted
05 January 2026
Copyright
© 2026 Feng, XIONG, GAO, Li and FENG. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Jinyu Li; duiping FENG
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