Frontiers in Genetics | Computational Genomics

Original Research

Accepted on 27 Jan 2026

Identification of programmed cell death and mitochondria correlated biomarkers for Kawasaki disease by integrated bioinformatics and machine-learning algorithms with RT-qPCR Verification

in Computational Genomics

Tengyang Wang
Chengyi Wang
YIWEI CHEN
Xiaofeng Guo

Frontiers in Genetics

Methods

Accepted on 27 Jan 2026

DWGCN: Distance-Weighted Graph Convolutional Network for Robust Spatial Domain Identification in Spatial Transcriptomics

in Computational Genomics

Chunfang Peng
Guobin Li
Jiamiao Wu
Qiao Fan
Xiaobo Guo

Frontiers in Genetics

Original Research

Published on 23 Jan 2026

Identifying druggable gene-related biomarkers in intervertebral disc degeneration through transcriptome sequencing and mendelian randomization analysis

in Computational Genomics

Keping Wang
Zuolong Wu
Guanghai Zhao
Shaolong Li
Yizhe Lou
Guanhong Pan
Guangyi Wang
Haihong Zhang

Frontiers in Genetics

doi 10.3389/fgene.2026.1627091

520 views

Original Research

Accepted on 21 Jan 2026

Mitophagy-Related Molecular Signatures in Ulcerative Colitis Revealed by Machine Learning and Molecular Dynamics

in Computational Genomics

Yanru Han
Weihua Ren
Sujuan Li
Zhenxia Zhao
Zhiqiang Lin
Fucheng Zhao

Frontiers in Genetics

135 views

Case Report

Accepted on 21 Jan 2026

Association of a Rare Single Nucleotide Variant in the KCNH2 Gene with Drug-Induced QT Prolongation and Computationally Predicted Pathogenicity

in Computational Genomics

TIANCI WANG
Charlene Norgan Radler
Mohanakrishnan Sathyamoorthy

Frontiers in Genetics

161 views

Original Research

Published on 21 Jan 2026

DFL-MHC: MHC identification model based on dual-stage training and multi-view feature fusion

in Computational Genomics

Yanjuan Li
Yiben Lin
Dong Chen

Frontiers in Genetics

doi 10.3389/fgene.2026.1774569

397 views

Original Research

Published on 21 Jan 2026

Coronary heart disease risk prediction based on GAIN imputation and interpretable machine learning

in Computational Genomics

Shulin Zhao
Baoyun Nan
Jun Guo
Wenkai Xu
Zhen Li

Frontiers in Genetics

doi 10.3389/fgene.2025.1752811

498 views

Original Research

Accepted on 16 Jan 2026

TCN-5mC: A Predictor of 5-methylcytosine sites based on multi-feature fusion and TCN-inspired block networks

in Computational Genomics

Cunwen Liu
Xuan Xiao
LongChang Wan
Weizhong Lin

Frontiers in Genetics

168 views

Brief Research Report

Published on 14 Jan 2026

Balancing speed and precision in protein folding: a comparison of AlphaFold2, ESMFold, and OmegaFold

in Computational Genomics

Anna Hýsková
Eva Maršálková
Petr Šimeček

Frontiers in Genetics

doi 10.3389/fgene.2025.1715037

858 views

Original Research

Published on 12 Jan 2026

FSFT6mA: a feature-synthesis fine-tuning framework for DNA 6mA site prediction

in Computational Genomics

Hong-Jin Yu
Ying Zhang
Dong-Jun Yu
Guansheng Zheng

Frontiers in Genetics

doi 10.3389/fgene.2025.1750223

563 views

Mini Review

Published on 09 Jan 2026

Reconstructing developmental lineages: a retrospective approach using somatic mutations and variant allele frequency

in Computational Genomics

Mahnoor Sajjad
Seong Gyu Kwon

Frontiers in Genetics

doi 10.3389/fgene.2025.1761810

782 views

Methods

Published on 07 Jan 2026

Resilience and evolutionary insights in PPI networks: comparative analysis of node resilience and centrality measures

in Computational Genomics

Jiarui Zhang

Frontiers in Genetics

doi 10.3389/fgene.2025.1613475

662 views

Original Research

Published on 07 Jan 2026

DDA-bench: a manually curated database for benchmarking datasets and baseline performance values in predicting drug-disease associations

in Computational Genomics

Han Xing
Yongjian Zhao

Frontiers in Genetics

doi 10.3389/fgene.2025.1755600

663 views

Original Research

Published on 05 Jan 2026

scVAR: integrating genomics and transcriptomics from single-cell RNA-seq —insights from leukemia case studies

in Computational Genomics

Ludovica Celli
Samuele Manessi
Matteo Barcella
Ivan Merelli

Frontiers in Genetics

doi 10.3389/fgene.2025.1604484

1,082 views

Original Research

Published on 05 Jan 2026

Lorentz-regularized interpretable VAE for multi-scale single-cell transcriptomic and epigenomic embeddings

in Computational Genomics

Zeyu Fu
Jiawei Fu
Chunlin Chen
Keyang Zhang
Song Wang

Frontiers in Genetics

doi 10.3389/fgene.2025.1713727

1,209 views

Methods

Published on 19 Dec 2025

fastMETA: a fast and efficient tool for multivariate meta-analysis of GWAS

in Computational Genomics

Georgios A. Manios
Dionysios Kandylas
Athanasios Kylonis
Pantelis G. Bagos
Panagiota I. Kontou

Frontiers in Genetics

doi 10.3389/fgene.2025.1718626

1,440 views

Editorial

Published on 19 Dec 2025

Editorial: Advances in circRNA research: disease associations and diagnostic innovations

in Computational Genomics

Quan Zou
Mengting Niu
Xiaoqing Ru

Frontiers in Genetics

doi 10.3389/fgene.2025.1759692

1,580 views

Brief Research Report

Published on 17 Dec 2025

Variance of Ks distribution corrects the bias in the divergence caused by the ancestral population size

in Computational Genomics

Mi-Jia Li
Xiao-Xue Li
Lin-Lin Xu
Bo-Wen Zhang

Frontiers in Genetics

doi 10.3389/fgene.2025.1725551

1,456 views

Original Research

Published on 16 Dec 2025

Identification and validation of biomarkers related to nicotinamide metabolic pathway activity in heart failure

in Computational Genomics

Jianping Du
Xiaoyu Yang
Shuxing Wu
Shuli Bi
Peng Wang
Lisong Cheng
Zhuhua Yao

Frontiers in Genetics

doi 10.3389/fgene.2025.1673314

1,168 views

Original Research

Published on 10 Dec 2025

Hyperlipidemia-associated specific modules and hub genes revealed by integrative methods of WGCNA and MetaDE

in Computational Genomics

Zhiyi Zhao
Yin Cao
Anna Gu
Hanxin Yao

Frontiers in Genetics

doi 10.3389/fgene.2025.1592778

1,234 views

Original Research

Published on 04 Dec 2025

Integrating GWAS and machine learning for disease risk prediction in the Taiwanese Hakka population

in Computational Genomics

Jing-Hong Xiao
Hsiao-Yen Kang
Li-Ching Wu
Tien Hsu
Chin-Pyng Wu
Li-Jen Su

Frontiers in Genetics

doi 10.3389/fgene.2025.1694084

1,634 views

Original Research

Published on 01 Dec 2025

Potential prognostic biomarkers in restenosis of peripheral arteries identified through comprehensive ceRNA network analysis

in Computational Genomics

Yulin Miao
Zongxin Li
Qianqian Sun
Gang Zhao
Guohang Shen
Haobo Zhang
Fengli Gao

Frontiers in Genetics

doi 10.3389/fgene.2025.1597644

1,344 views

Methods

Published on 26 Nov 2025

OFGPMA: Optimal frequency graph representation learning for pseudogene and miRNA association prediction

in Computational Genomics

Yongbin Zeng
Lixiang Xiong
Yungui Luo

Frontiers in Genetics

doi 10.3389/fgene.2025.1643921

981 views

Original Research

Published on 26 Nov 2025

DMAGCL: A dual-masked adaptive graph contrastive learning framework for predicting circRNA-drug sensitivity

in Computational Genomics

Peng Wang
Yuqi Guo
Zejun Li
Di Tang
Mingming Qi
Zhanyi Zhu
Lichao Zhang

Frontiers in Genetics

doi 10.3389/fgene.2025.1721716

1,397 views
1 citation

2,647 articles

articles

Identification of programmed cell death and mitochondria correlated biomarkers for Kawasaki disease by integrated bioinformatics and machine-learning algorithms with RT-qPCR Verification

DWGCN: Distance-Weighted Graph Convolutional Network for Robust Spatial Domain Identification in Spatial Transcriptomics

Identifying druggable gene-related biomarkers in intervertebral disc degeneration through transcriptome sequencing and mendelian randomization analysis

Mitophagy-Related Molecular Signatures in Ulcerative Colitis Revealed by Machine Learning and Molecular Dynamics

Association of a Rare Single Nucleotide Variant in the KCNH2 Gene with Drug-Induced QT Prolongation and Computationally Predicted Pathogenicity

DFL-MHC: MHC identification model based on dual-stage training and multi-view feature fusion

Coronary heart disease risk prediction based on GAIN imputation and interpretable machine learning

TCN-5mC: A Predictor of 5-methylcytosine sites based on multi-feature fusion and TCN-inspired block networks

Balancing speed and precision in protein folding: a comparison of AlphaFold2, ESMFold, and OmegaFold

FSFT6mA: a feature-synthesis fine-tuning framework for DNA 6mA site prediction

Reconstructing developmental lineages: a retrospective approach using somatic mutations and variant allele frequency

Resilience and evolutionary insights in PPI networks: comparative analysis of node resilience and centrality measures

DDA-bench: a manually curated database for benchmarking datasets and baseline performance values in predicting drug-disease associations

scVAR: integrating genomics and transcriptomics from single-cell RNA-seq —insights from leukemia case studies

Lorentz-regularized interpretable VAE for multi-scale single-cell transcriptomic and epigenomic embeddings

fastMETA: a fast and efficient tool for multivariate meta-analysis of GWAS

Editorial: Advances in circRNA research: disease associations and diagnostic innovations

Variance of Ks distribution corrects the bias in the divergence caused by the ancestral population size

Identification and validation of biomarkers related to nicotinamide metabolic pathway activity in heart failure

Hyperlipidemia-associated specific modules and hub genes revealed by integrative methods of WGCNA and MetaDE

Integrating GWAS and machine learning for disease risk prediction in the Taiwanese Hakka population

Potential prognostic biomarkers in restenosis of peripheral arteries identified through comprehensive ceRNA network analysis

OFGPMA: Optimal frequency graph representation learning for pseudogene and miRNA association prediction

DMAGCL: A dual-masked adaptive graph contrastive learning framework for predicting circRNA-drug sensitivity