REVIEW article
Front. Lab Chip Technol.
Sec. Organ on a Chip
This article is part of the Research TopicExploring Organogenesis and Disease Models with Organoids and Organ-on-a-Chip TechnologiesView all articles
Engineering Liver Organoids-on-a-Chip
Provisionally accepted
- 1Purdue University, West Lafayette, United States
- 2Indiana University Indianapolis, Indianapolis, United States
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Advances in stem cell biology and microengineering have led to the emergence of liver organoids-ona-chip systems, hybrid platforms that integrate self-organizing three-dimensional organoids with microfluidic devices. These technologies enable more physiologically relevant modeling of human liver biology by enhancing organoid maturation, incorporating dynamic cues such as flow and shear stress, and facilitating multicellular interactions across parenchymal and non-parenchymal compartments. As a result, they provide powerful opportunities to investigate liver development, interrogate mechanisms of disease progression, and assess pharmacological responses with higher fidelity than conventional models. Applications span from studying steatohepatitis and fibrosis to evaluating drug-induced liver injury and patient-specific variability in metabolism. In this Review, we highlight recent progress in liver organoids-on-a-chip systems, discuss their potential in personalized medicine and predictive toxicology, and outline current technical challenges and translational opportunities that will shape their future impact on therapeutic discovery and precision health.
Keywords: liver organoids1, organ-on-a-chip2, Stem cells3, tissue engineering4, microphysiologcal system5
Received: 05 Oct 2025; Accepted: 13 Nov 2025.
Copyright: © 2025 Zhu, Dressman, Gall and Park. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Sunghee Estelle Park, park1713@purdue.edu
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