REVIEW article
Front. Lupus
Sec. Clinical Research and Treatment in Lupus
Volume 3 - 2025 | doi: 10.3389/flupu.2025.1679564
Scavenger Receptors: Key Players in the Immunological Puzzle of Lupus
Provisionally accepted
- University of Massachusetts Chan Medical School Department of Medicine, Worcester, United States
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Scavenger receptors (SRs) play an important role in the innate immune response by recognizing and binding a variety of ligands to initiate the removal of both altered self-and non-self-antigens. Over the last two decades, SRs have become a forefront for their role influencing and contributing to inflammatory disease pathways. The findings discussed in this review show that the immunological role SRs play is 1) found in multiple organ systems and not limited to one disease or subset of symptoms; 2) part of both the innate and adaptive immune response in addition to influencing inflammatory signaling via non-immune cell subtypes; 3) both pro-or anti-inflammatory depending on which SR class or cell signaling pathway is being observed; 4) potentially useful for the development of therapeutics and diagnostic or prognostic biomarkers for autoimmune disease pathology. Understanding the role of SRs in the context of inflammation and autoimmunity will shed some light on the comprehension of heterogeneous diseases, such as Systemic Lupus Erythematosus.
Keywords: Scavenger receptors (SRs), Autoimmunity, systemic lupus erythematosus (SLE), Inflammation, Cardinal signs
Received: 04 Aug 2025; Accepted: 30 Sep 2025.
Copyright: © 2025 Hanh, Chitre, Shepard and Ramirez-Oritz. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Zaida G Ramirez-Oritz, zaida.ramirezortiz@umassmed.edu
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