MINI REVIEW article
Front. Med.
Sec. Dermatology
This article is part of the Research TopicRegenerative Medicine in DermatologyView all 5 articles
Modulating Rheology and Bioactivity in Dermal Fillers: The Emerging Role of Platelet-Rich Plasma (PRP)
Provisionally accepted
- 1University Institute for Regenerative Medicine & Oral Implantology, UIRMI (UPV/EHU-Fundación Eduardo Anitua), Vitoria, Spain
- 2BTI Biotechnology Institute SL, Vitoria-Gasteiz, Spain
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This review explores the concept of dilutional rheomodulation in dermal fillers with the addition of platelet-rich plasma (PRP) and its potential to improve both aesthetic and regenerative outcomes. PRP is a biological product rich in growth factors and cytokines derived from the patient's own blood, which plays a significant role in tissue regeneration and healing. According to previous studies that utilized titrated aqueous solutions as solvents, it is hypothesized that incorporating PRP into different dermal filler formulations may be effective for modulating the rheological parameteres of dermal fillers while providing regenerative and immunomodulatory properties, potentially improving biocompatibility, injectability, distribution, and overall tissue integration as suggested by preliminary investigations. This combined approach may reduce severe adverse effects associated with filler injections while enhancing their biostimulatory effects. Moreover, PRP has been shown to stimulate collagen production and promote skin regeneration, which may extend the filler's longevity and improve skin texture and elasticity. Although early studies suggest positive outcomes, further clinical trials are needed to determine optimal dilution ratios, establish best practices, and assess long-term safety and efficacy. This review highlights the promising potential of PRP-filler combinations in advancing aesthetic procedures through the integration of immediate volumization with regenerative skin enhancement.
Keywords: biostimulation, Dermal filler, dilutional rheomodulation, Platelet-Rich Plasma, Regenerative therapy
Received: 20 Oct 2025; Accepted: 05 Dec 2025.
Copyright: © 2025 Anitua, Tierno and Alkhraisat. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Eduardo Anitua
Roberto Tierno
Mohammad Hamdan Alkhraisat
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