REVIEW article
Front. Mol. Biosci.
Sec. Molecular Diagnostics and Therapeutics
Volume 12 - 2025 | doi: 10.3389/fmolb.2025.1615393
This article is part of the Research TopicOncolytic Virotherapy: Volume IIIView all articles
Insights from Veterinary Models for Advancing Oncolytic Virotherapy Through Comparative Oncology
Provisionally accepted
- 1University of Tabuk, Tabuk, Saudi Arabia
- 2Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk, Saudi Arabia
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Cancer is a complex disease affecting both humans and animals. Comparative immuno-oncology explores immune responses across species to develop effective cancer therapies. Oncolytic viruses (OVs) serve as both direct tumor-lysing agents and immune stimulants, making them an attractive therapeutic option. This review highlights the role of naturally occurring tumors in animal models for OV-based cancer immunotherapy. We examine immune responses in different species, the latest advancements in OV therapy, and the role of precision medicine in veterinary oncology.Understanding these comparative aspects enhances OV translation from preclinical to clinical applications in both veterinary and human oncology.
Keywords: Oncolytic Viruses, comparative immuno-oncology, Animal Models, Immunotherapy, veterinary oncology
Received: 21 Apr 2025; Accepted: 15 May 2025.
Copyright: © 2025 Alkayyal. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Almohanad A Alkayyal, University of Tabuk, Tabuk, Saudi Arabia
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