MINI REVIEW article
Front. Mol. Biosci.
Sec. Lipids, Membranes and Membranous Organelles
Volume 12 - 2025 | doi: 10.3389/fmolb.2025.1638737
This article is part of the Research TopicCurrent Advances in Primary and Motile Cilia Research for Developing New MedicineView all articles
Kinase-dependent regulation of ciliary protein transport and its implications for therapy
Provisionally accepted
- Osaka University, Suita, Japan
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Primary cilia are evolutionarily conserved microtubule-based structures that extend from the surfaces of many different cell types and decode a wide range of extracellular chemical and physical stimuli. Ciliary defects cause human diseases, termed ciliopathies, which are characterized by a variety of symptoms, such as developmental and sensory abnormalities. The formation and function of primary cilia depend on intraflagellar transport (IFT), which is a bidirectional protein transport system coordinated by three multi-subunit protein complexes with kinesin and dynein motors along the ciliary axoneme. Accumulating evidence has demonstrated that several serine-threonine kinases play key roles in the regulation of IFT. Here, we review the current understanding of the roles of these kinases during the IFT process, as well as their regulatory mechanisms, physiological and pathophysiological significance, and potential to treat ciliopathies and age-related obesity.
Keywords: CILK1, ICK, MAK, ciliary tip, Retinitis Pigmentosa
Received: 31 May 2025; Accepted: 13 Jun 2025.
Copyright: © 2025 Chaya, Ayano and Furukawa. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Taro Chaya, Osaka University, Suita, Japan
Takahisa Furukawa, Osaka University, Suita, Japan
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