ORIGINAL RESEARCH article
Front. Mol. Biosci.
Sec. Molecular Diagnostics and Therapeutics
Transcriptomic profiling of chlorogenic acid and taurine treatment in human skin cells provides insights into cellular senescence mechanisms
Provisionally accepted
Beomsu Kim1,2,3,4
Joong-Gon Shin5
In-Shik Hong1,2Yeeun Ahn1,2
Jung Yeon Seo5Jae Young Shin5
Sooyeon Lee5Seung-Hyun Jun5Eui Taek Jeong5Hyeonbin Jo1,2Mi-So Park1,2Dan Say Kim1,2
Nae Gyu Kang5*
Yunkwan Kim5*
Hong-Hee Won1,2*- 1Sungkyunkwan University, Jongno-gu, Republic of Korea
- 2Samsung Advanced Institute for Health Sciences & Technology, Seoul, Republic of Korea
- 3Boston Children's Hospital, Boston, United States
- 4Broad Institute, Cambridge, United States
- 5LG H&H Co Ltd, Seoul, Republic of Korea
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Chlorogenic acid (CGA) and taurine are well-known antioxidant compounds reported to reduce skin cellular senescence. However, the biological mechanisms underlying their skin-protective effects remain unclear. In this study, we conducted transcriptome-wide RNA sequencing to profile gene expression changes in human epidermal keratinocytes, melanocytes, and fibroblasts following treatment with CGA, taurine, or their combination. A total of 197 differentially expressed genes (DEGs) were identified, of which 62 were prioritized as aging-related DEGs based on their relevance to skin aging anti-senescence-associated pathways, highlighting regulatory transcription factors including TGFB2, ETS1, and EGR1. Co-treatment enhanced the transcriptional effects of CGA and taurine, with several genes exhibiting synergistic responses. By identifying key genes and pathways that contribute to cellular longevity in human skin, this study provides molecular insights for developing anti-aging strategies with potential applications in dermatology.
Keywords: Chlorogenic Acid, RNA sequencing, Skin Aging, Taurine, Transcriptomics
Received: 17 Nov 2025; Accepted: 04 Feb 2026.
Copyright: © 2026 Kim, Shin, Hong, Ahn, Seo, Shin, Lee, Jun, Jeong, Jo, Park, Kim, Kang, Kim and Won. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Nae Gyu Kang
Yunkwan Kim
Hong-Hee Won
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.