REVIEW article
Front. Mol. Biosci.
Sec. Molecular Diagnostics and Therapeutics
This article is part of the Research TopicEpigenetic and Genetic Mechanisms Underlying Cardiovascular Diseases and Neurodevelopmental Disorders, Volume IIView all 7 articles
Novel Drugs Targeting Genetic Variants: Current Applications and Future Prospects in Heart Failure Treatment
Provisionally accepted
- 1Guangdong Medical University, Zhanjiang, China
- 2Longgang District People's Hospital of Shenzhen, Shenzhen, China
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Chronic heart failure (HF) is a common and frequently occurring disease worldwide, and its traditional treatment methods are undergoing earth-shaking changes. This study analyzes novel drugs targeting genetic mutations that have been launched in recent years, such as sodium-glucose co-transporter 2 inhibitors, angiotensin receptor neprilysin inhibitors, soluble guanylate cyclase, cardiac myosin activators, potassium channel openers, and vasopressin receptor antagonists, compares the drug action mechanisms, key clinical trial data in the research, and the application of real-world research, and discusses the clinical value and existing problems of new drugs.
Keywords: application, chronic heart failure, novel drugs, targeted genetic mutation drugs, Treatment
Received: 06 Jan 2026; Accepted: 06 Feb 2026.
Copyright: © 2026 Li, Bai and Luo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yumei Luo
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