Frontiers in Molecular Neuroscience

Original Research

Published on 02 Apr 2026

Exploring the mechanism of Yin Huo decoction in PCPA-induced depression mice: a metabolomics and network pharmacology approach

Yu Zhou
Lu Jia Liu
Yue Zhang
Wen Wen Wang
Dan Hong Xu

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1725806

1,519 views

Brief Research Report

Published on 20 Jan 2026

Distinct spatial distribution of potentiated dendritic spines in encoding- and recall-activated hippocampal neurons

Francesco Gobbo
Ajesh Jacob
Bruno Pinto
Marco Mainardi
Laura Cancedda
Antonino Cattaneo

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1751677

2,372 views
1 citation

Mini Review

Published on 16 Jan 2026

Endoplasmic reticulum protein retention and disturbed proteostasis is a common pathology for a subset of autism: evidence from mutations in GABAA receptors and GABA transporter 1

Jing-Qiong Kang
Aiden Delahanty

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1671331

2,100 views

Brief Research Report

Published on 15 Jan 2026

Hsd17b7 undergoes dynamic subcellular localization during Neuro2a differentiation

Matthew Bispo
Macey Pennay
Joe C. Brague
Ashley M. Driver

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1639803

2,173 views

Original Research

Published on 13 Jan 2026

Gene expression asymmetry in Parkinson’s disease: variation of CCT gene expression is correlated with hemisphere specific severity

Steven E. Pierce
Edwin J. C. van der Schans
Thomas M. Goralski
Elizabeth Ensink
Peipei Li
Michael X. Henderson
Gerhard A. Coetzee

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1743557

2,681 views

Review

Published on 12 Jan 2026

Structure and function of neurovascular unit in arterial hypertension

Ewa Kozniewska
Marta Aleksandrowicz

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1714892

2,944 views
3 citations

Original Research

Published on 12 Jan 2026

Genetic and metabolic inflammation signatures in chronic inflammatory demyelinating polyneuropathy: the role of IL18 polymorphisms and short-chain fatty acids

Szymon Andrusiów
Marta Dratwa-Kuzmin
Piotr Łacina
Patrycja Bochen
Klaudia Gładysz
Bogumiła Szponar
Magdalena Koszewicz
Katarzyna Bogunia-Kubik

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1738817

2,498 views

Review

Published on 12 Jan 2026

Role of FK506 binding protein 51 in central nervous system diseases

Haokun Peng
Yanhao Wei
Yanmei Qiu
Rentang Bi
Longhai Zeng
Bo Hu
Yanan Li

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1725945

3,516 views

Original Research

Published on 12 Jan 2026

Genetic evidence for a functional association between Parkinson’s disease proteins leucine-rich repeat kinase 2 and α-synuclein during axonal transport

Piyali Chakraborty
Pratima Bajgain
Jing Huang
Rakibul Islam
Rupkatha Banerjee
Shermali Gunawardena

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1667839

3,026 views

Original Research

Published on 12 Jan 2026

Small molecule FTO inhibitor MO-I-500 protects differentiated SH-SY5Y neuronal cells from oxidative stress

Denise Greco
Zuzana Čočková
Debanjan Das
Akash S. Mali
Jiří Novotný
Mark J. Olsen
Petr Telenský

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1736173

2,565 views
2 citations

Opinion

Published on 12 Jan 2026

Astrocyte epigenetics as a priority area in neuroscience research

Itzy E. Morales Pantoja
C. David Mintz

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1716805

3,991 views
4 citations

Editorial

Published on 12 Jan 2026

Editorial: Advancing therapeutics for Alzheimer's disease and related dementias through multi-omics data analysis in ethnically diverse populations

Anjali Garg
Ravindra Kumar
Rajan Shrivastava
Deepesh Kumar Gupta
Bandana Kumari
Manish Kumar

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1767630

1,773 views

Original Research

Published on 12 Jan 2026

Omaveloxolone promotes functional recovery of spinal cord injury by reducing inflammatory response and regulating macrophage polarization

Pengtian Zhao
Wenlu Yuan
Jiayi Zhang
Erke Gao
Dejing Zhang
Zhuolin Wu
Yue Zhang
Junbo Chen
Dunxu Hu
Baoyou Fan

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1737798

2,302 views
1 citation

Review

Published on 09 Jan 2026

Putative role of TMEM165 in congenital cardiomyopathies

Paula P. Gonçalves

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1692968

2,443 views

Original Research

Published on 07 Jan 2026

CHI3L1 monoclonal antibody therapy mitigates cognitive impairment by inhibiting neuroinflammation through ERK and NF-κB pathway in Tg2576 mice

Hyeon Joo Ham
Seung Sik Park
Yong Sun Lee
Tae Hun Kim
Dong Ju Son
Ji-Hun Kim
Key-Hwan Lim
Hanseul Park
Hye Jin Lee
Jaesuk Yun

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1728279

3,048 views

Original Research

Published on 05 Jan 2026

Interactome screening implicates BAG6 as a suppressor of UBQLN2 misfolding in ALS/FTD

Sang Hwa Kim
Claire E. Boos
Mark Scalf
Akasha K. Wilkemeyer
Lloyd M. Smith
Randal S. Tibbetts

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1720347

2,790 views

Original Research

Published on 05 Jan 2026

Regional and temporal dynamics of DNA methylation and epigenetic gene regulation in response to binge-like alcohol exposure in the adolescent mouse brain

Amine Cherif
Amine Bourzam
Zeineb Fridhi
Hanani Boukhawiye
Clement Guillou
Pascal Cosette
Sami Zekri
Jérôme Leprince
David Vaudry
Olfa Masmoudi-Kouki

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1716792

2,992 views

Mini Review

Published on 05 Jan 2026

Potential role of stress granules and myogranules in amyotrophic lateral sclerosis

Saddam Muhammad Ishaq
Aaron P. Russell

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1686230

2,883 views
2 citations

Original Research

Published on 17 Dec 2025

Nrf2/HO-1-sulfiredoxin1 pathway involved in nanobubble hydrogen-dissolved water-mediated protective effects by ultrasound-guided early local injection in a rat model of chronic constriction injury-induced neuropathic pain

Junmin Yu
Zixiao Yin
Hongmin Ma
Bing Zhang
Chao Meng

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1666575

2,086 views
1 citation

Original Research

Published on 10 Dec 2025

A phage displaying an Aβ-interacting peptide mitigates neurotoxicity and prevents Aβ-driven gene expression changes

Laura Maria De Plano
Luigi Chiricosta
Simone D’Angiolini
Alessandra Saitta
Alessandra Trainito
Serena Silvestro
Sabrina Conoci
Salvatore Oddo
Antonella Caccamo

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1716626

2,832 views

Original Research

Published on 08 Dec 2025

Effects of voluntary wheel running on appetite-regulating peptides and neuroinflammation in the hypothalamus of ovariectomized middle-aged mice

Mateusz Grabowski
Konstancja Grabowska
Magdalena Kostka
Natalia Pondel
Halina Jędrzejowska-Szypułka
Andrzej Małecki
Jarosław J. Barski
Marta Nowacka-Chmielewska

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1698306

2,861 views
1 citation

Original Research

Published on 05 Dec 2025

Unraveling proteomic signatures and neuroinflammatory networks in a CCI rat model of early sciatica: insights for neuropathic pain mechanisms

Xingjuan Li
Xiaojie Wang
Jinhui Song
Bin Jiang
Yaqin Wen
Yang Wang
Bo Liu
Xiao Zheng

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1674151

3,344 views
1 citation

Original Research

Published on 03 Dec 2025

Inhibition of pro-apoptotic UPR pathways PERK/CHOP and IRE1/JNK protects differentiated SH-SY5Y cells against rotenone-induced toxicity

Natalia Siwecka
Wioletta Rozpȩdek-Kamińska
Michał Golberg
Wojciech Wiese
Grzegorz Galita
Ireneusz Majsterek

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1700897

3,442 views
5 citations

Opinion

Published on 03 Dec 2025

Reelin signaling as a translational rheostat: linking synaptic homeostasis to neurodevelopment and neurodegeneration

Murat S. Durakoglugil

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1731914

2,948 views

182 Publications

volumes

Exploring the mechanism of Yin Huo decoction in PCPA-induced depression mice: a metabolomics and network pharmacology approach

Distinct spatial distribution of potentiated dendritic spines in encoding- and recall-activated hippocampal neurons

Endoplasmic reticulum protein retention and disturbed proteostasis is a common pathology for a subset of autism: evidence from mutations in GABAA receptors and GABA transporter 1

Hsd17b7 undergoes dynamic subcellular localization during Neuro2a differentiation

Gene expression asymmetry in Parkinson’s disease: variation of CCT gene expression is correlated with hemisphere specific severity

Structure and function of neurovascular unit in arterial hypertension

Genetic and metabolic inflammation signatures in chronic inflammatory demyelinating polyneuropathy: the role of IL18 polymorphisms and short-chain fatty acids

Role of FK506 binding protein 51 in central nervous system diseases

Genetic evidence for a functional association between Parkinson’s disease proteins leucine-rich repeat kinase 2 and α-synuclein during axonal transport

Small molecule FTO inhibitor MO-I-500 protects differentiated SH-SY5Y neuronal cells from oxidative stress

Astrocyte epigenetics as a priority area in neuroscience research

Editorial: Advancing therapeutics for Alzheimer's disease and related dementias through multi-omics data analysis in ethnically diverse populations

Omaveloxolone promotes functional recovery of spinal cord injury by reducing inflammatory response and regulating macrophage polarization

Putative role of TMEM165 in congenital cardiomyopathies

CHI3L1 monoclonal antibody therapy mitigates cognitive impairment by inhibiting neuroinflammation through ERK and NF-κB pathway in Tg2576 mice

Interactome screening implicates BAG6 as a suppressor of UBQLN2 misfolding in ALS/FTD

Regional and temporal dynamics of DNA methylation and epigenetic gene regulation in response to binge-like alcohol exposure in the adolescent mouse brain

Potential role of stress granules and myogranules in amyotrophic lateral sclerosis

Nrf2/HO-1-sulfiredoxin1 pathway involved in nanobubble hydrogen-dissolved water-mediated protective effects by ultrasound-guided early local injection in a rat model of chronic constriction injury-induced neuropathic pain

A phage displaying an Aβ-interacting peptide mitigates neurotoxicity and prevents Aβ-driven gene expression changes

Effects of voluntary wheel running on appetite-regulating peptides and neuroinflammation in the hypothalamus of ovariectomized middle-aged mice

Unraveling proteomic signatures and neuroinflammatory networks in a CCI rat model of early sciatica: insights for neuropathic pain mechanisms

Inhibition of pro-apoptotic UPR pathways PERK/CHOP and IRE1/JNK protects differentiated SH-SY5Y cells against rotenone-induced toxicity

Reelin signaling as a translational rheostat: linking synaptic homeostasis to neurodevelopment and neurodegeneration