ORIGINAL RESEARCH article

Front. Nanotechnol.

Sec. Biomedical Nanotechnology

Volume 7 - 2025 | doi: 10.3389/fnano.2025.1564954

Antiglycating activity of biomimetically synthesized magnetic copper ferrite nanoparticles: Inhibition of methylglyoxal-derived AGEs

Provisionally accepted
Saheem  AhmadSaheem Ahmad1*Uzma  ShahabUzma Shahab2Jalaluddin  AshrafJalaluddin Ashraf3Amjad R.  AlyahyawiAmjad R. Alyahyawi2Mohammad  Azam AnsariMohammad Azam Ansari4Sana  FarmaSana Farma5Ahmed  AlshammariAhmed Alshammari2Rihab  AkashaRihab Akasha2Sarah  AsiriSarah Asiri4Paridhi  PuriParidhi Puri6Afreen  KhanamAfreen Khanam7
  • 1College of Applied Medical Science, University of Hail, Hail, Saudi Arabia
  • 2University of Hail, Ha'il, Hail, Saudi Arabia
  • 3Samarkand State Medical University, Samarkand, Uzbekistan
  • 4Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia
  • 5Ashoka institute of technology and management, Varanasi, India
  • 6Chandigarh University, Mohali, Punjab, India
  • 7Mangalayatan University, Beswan, Uttar Pradesh, India

The final, formatted version of the article will be published soon.

The nonenzymatic glycation process initiates a harmful cycle that generates various intermediate compounds, leading to carbonyl and oxidative stress, and ultimately resulting in the formation of advanced glycation end products (AGEs). AGEs have been implicated as key factors in the development of several diseases, including neurodegenerative conditions like Parkinson's and Alzheimer's diseases, as well as complications associated with diabetes. Given the potential impact of AGEs on these diseases, this study explores the role of copper ferrite nanoparticles (CuFe2O4NPs) in inhibiting the formation of these harmful intermediates and AGEs. Magnetic CuFe2O4 nanoparticles were synthesized using Aloe vera leaf extracts and their effects on AGE formation were assessed. Using both biophysical and biochemical approaches, the study demonstrates that CuFe2O4 NPs have significant anti-glycation properties, which help reduce or prevent AGE formation while maintaining protein structure. These findings suggest that CuFe2O4 NPs may offer therapeutic potential in addressing AGE-related diseases, particularly those linked to diabetes and its complications.

Keywords: methylglyoxal, ages, CuFe2O4 NPs, Antiglycation, Nanoparticles

Received: 22 Jan 2025; Accepted: 22 May 2025.

Copyright: © 2025 Ahmad, Shahab, Ashraf, Alyahyawi, Ansari, Farma, Alshammari, Akasha, Asiri, Puri and Khanam. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Saheem Ahmad, College of Applied Medical Science, University of Hail, Hail, Saudi Arabia

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