ORIGINAL RESEARCH article
Front. Nanotechnol.
Sec. Biomedical Nanotechnology
Volume 7 - 2025 | doi: 10.3389/fnano.2025.1564954
Antiglycating activity of biomimetically synthesized magnetic copper ferrite nanoparticles: Inhibition of methylglyoxal-derived AGEs
Provisionally accepted
Saheem Ahmad1*
Uzma Shahab2
Jalaluddin Ashraf3Amjad R. Alyahyawi2
Mohammad Azam Ansari4Sana Farma5Ahmed Alshammari2
Rihab Akasha2
Sarah Asiri4Paridhi Puri6Afreen Khanam7- 1College of Applied Medical Science, University of Hail, Hail, Saudi Arabia
- 2University of Hail, Ha'il, Hail, Saudi Arabia
- 3Samarkand State Medical University, Samarkand, Uzbekistan
- 4Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia
- 5Ashoka institute of technology and management, Varanasi, India
- 6Chandigarh University, Mohali, Punjab, India
- 7Mangalayatan University, Beswan, Uttar Pradesh, India
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The nonenzymatic glycation process initiates a harmful cycle that generates various intermediate compounds, leading to carbonyl and oxidative stress, and ultimately resulting in the formation of advanced glycation end products (AGEs). AGEs have been implicated as key factors in the development of several diseases, including neurodegenerative conditions like Parkinson's and Alzheimer's diseases, as well as complications associated with diabetes. Given the potential impact of AGEs on these diseases, this study explores the role of copper ferrite nanoparticles (CuFe2O4NPs) in inhibiting the formation of these harmful intermediates and AGEs. Magnetic CuFe2O4 nanoparticles were synthesized using Aloe vera leaf extracts and their effects on AGE formation were assessed. Using both biophysical and biochemical approaches, the study demonstrates that CuFe2O4 NPs have significant anti-glycation properties, which help reduce or prevent AGE formation while maintaining protein structure. These findings suggest that CuFe2O4 NPs may offer therapeutic potential in addressing AGE-related diseases, particularly those linked to diabetes and its complications.
Keywords: methylglyoxal, ages, CuFe2O4 NPs, Antiglycation, Nanoparticles
Received: 22 Jan 2025; Accepted: 22 May 2025.
Copyright: © 2025 Ahmad, Shahab, Ashraf, Alyahyawi, Ansari, Farma, Alshammari, Akasha, Asiri, Puri and Khanam. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Saheem Ahmad, College of Applied Medical Science, University of Hail, Hail, Saudi Arabia
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