Skip to main content

ORIGINAL RESEARCH article

Front. Neurol., 09 June 2023
Sec. Neurocritical and Neurohospitalist Care
This article is part of the Research Topic Machine Intelligence and Technology: Clinical Applications in Neurology View all 8 articles

Delirium detection using wearable sensors and machine learning in patients with intracerebral hemorrhage

\r\nAbdullah Ahmed&#x;Abdullah Ahmed1Augusto Garcia-Agundez,&#x;Augusto Garcia-Agundez1,2Ivana PetrovicIvana Petrovic1Fatemeh RadaeiFatemeh Radaei1James FifeJames Fife1John ZhouJohn Zhou1Hunter KarasHunter Karas1Scott MoodyScott Moody3Jonathan DrakeJonathan Drake3Richard N. JonesRichard N. Jones4Carsten Eickhoff
&#x;Carsten Eickhoff1*Michael E. Reznik
&#x;Michael E. Reznik3*
  • 1Brown Center for Biomedical Informatics, Brown University, Providence, RI, United States
  • 2IMDEA Networks Institute, Madrid, Spain
  • 3Department of Neurology, Brown University, Providence, RI, United States
  • 4Department of Psychiatry, Brown University, Providence, RI, United States

Objective: Delirium is associated with worse outcomes in patients with stroke and neurocritical illness, but delirium detection in these patients can be challenging with existing screening tools. To address this gap, we aimed to develop and evaluate machine learning models that detect episodes of post-stroke delirium based on data from wearable activity monitors in conjunction with stroke-related clinical features.

Design: Prospective observational cohort study.

Setting: Neurocritical Care and Stroke Units at an academic medical center.

Patients: We recruited 39 patients with moderate-to-severe acute intracerebral hemorrhage (ICH) and hemiparesis over a 1-year period [mean (SD) age 71.3 (12.20), 54% male, median (IQR) initial NIH Stroke Scale 14.5 (6), median (IQR) ICH score 2 (1)].

Measurements and main results: Each patient received daily assessments for delirium by an attending neurologist, while activity data were recorded throughout each patient's hospitalization using wrist-worn actigraph devices (on both paretic and non-paretic arms). We compared the predictive accuracy of Random Forest, SVM and XGBoost machine learning methods in classifying daily delirium status using clinical information alone and combined with actigraph data. Among our study cohort, 85% of patients (n = 33) had at least one delirium episode, while 71% of monitoring days (n = 209) were rated as days with delirium. Clinical information alone had a low accuracy in detecting delirium on a day-to-day basis [accuracy mean (SD) 62% (18%), F1 score mean (SD) 50% (17%)]. Prediction performance improved significantly (p < 0.001) with the addition of actigraph data [accuracy mean (SD) 74% (10%), F1 score 65% (10%)]. Among actigraphy features, night-time actigraph data were especially relevant for classification accuracy.

Conclusions: We found that actigraphy in conjunction with machine learning models improves clinical detection of delirium in patients with stroke, thus paving the way to make actigraph-assisted predictions clinically actionable.

1. Introduction

Delirium occurs frequently in critically ill patients and has consistently been associated with higher mortality and worse overall outcomes (1). However, the diagnosis and detection of delirium remains challenging in many patient populations, as existing screening tools are unreliable in patients with stroke (2), neurocritical illness (3), and dementia (4). Further, because the diagnosis and detection of delirium relies on bedside testing, identifying at-risk patients across all hospital settings is highly labor intensive. Automated methods of delirium screening would therefore fill a critical need in the care of patients whose delirium may otherwise go undetected due to superimposed neurologic deficits, and potentially for critically ill patients as a whole.

We have previously described fluctuations of consciousness as a potential behavioral biomarker that corresponds to delirium in patients with stroke while also potentially identifying cases of delirium that went undetected by conventional screening tools (5). Additionally, we have found that these fluctuations may correspond to long-term outcomes in a subset of patients with hemorrhagic stroke (6). However, determining levels of consciousness still depends on frequent bedside assessments and may therefore be prohibitive. Given that motor activity is often heavily factored into clinical measurements of consciousness (7), and that psychomotor changes are a hallmark of delirium (8), continuous measurements of motor activity may represent a promising behavioral biomarker to aid in delirium detection.

Various devices for measuring motor activity exist, though wearable sensors such as wrist actigraphs are especially appealing due to their ease of use and relatively low cost. Such devices are commonly used in outpatient sleep medicine settings (9), and have increasingly been utilized in studies attempting to measure physical activity (10) and sleep (11) in the intensive care unit (ICU). However, actigraphy in ICU settings may be contaminated by externally mediated activity arising from clinical care. As a result, although wrist actigraphs have also been considered as a potential means of predicting delirium, existing studies have thus far shown mixed results using conventional statistical methods (1214).

In this study, we aimed to mitigate some of this externally mediated artifact by collecting actigraphy data from a cohort of critically ill patients with hemiparesis due to acute intracerebral hemorrhage (ICH). Owing to marked differences in activity profiles between paretic and non-paretic sides, we aimed to leverage actigraphy data from both wrists as a within-patient control. Further, the heterogeneous nature of individual activity profiles and delirium cases lends itself to advanced analysis using machine learning-based techniques. We therefore designed this study to test the feasibility of this novel approach.

2. Materials and methods

2.1. Study population

We prospectively screened all patients admitted to Rhode Island Hospital's Neurocritical Care Unit (NCCU) or Stroke Unit (SU) with acute intracerebral hemorrhage (ICH) over a 1-year period from 2018 to 2019 for potential enrollment. We included patients with moderate-to-severe supratentorial ICH [National Institutes of Health (NIH) stroke scale ≥ 5] and hemiparesis, specifically focusing on supratentorial ICH because of the higher likelihood of cognitive symptoms occurring in conjunction with motor symptoms as compared to patients with brainstem or cerebellar hematomas. We excluded patients with previous limb amputation or significant pre-morbid functional disability requiring assistance with their daily activities (as assessed using the modified Rankin Scale), as well as patients with devastating strokes considered to have a high likelihood of mortality. All patients were enrolled within 72 h of admission.

2.2. Delirium assessments

Daily delirium assessments were performed each afternoon by an attending neurocritical care or behavioral neurologist, with the exception of weekends and holidays. Delirium was diagnosed according to Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria (15): disturbances in attention and awareness (often accompanied by disturbances in other cognitive domains, such as psychomotor slowing or agitation, disorientation, disorganized thinking, impaired executive function, or perceptual disturbance) that develop over a short period of time and tend to fluctuate, represent a change in function, and are due to an underlying medical condition or toxic/withdrawal syndrome. Assessments were supplemented by interviews and history obtained from patients' nurses and clinical providers, family members, and the medical chart. Joint adjudication sessions were held between the participating neurologists to obtain consensus on delirium diagnoses for each patient.

2.3. Actigraph data collection

Wrist actigraphs (Micro Motionlogger, Ambulatory Monitoring, Inc., Ardsley, NY) were placed on both wrists for each patient and left in place for the duration of their stay in the NCCU or SU. Actigraphs were otherwise only purposefully removed in anticipation of magnetic resonance imaging scans as a safety precaution and were then replaced thereafter.

Each actigraph was configured to collect activity data in 1-min epochs. These data were then aggregated by proprietary algorithms from the Action4 software package (Ambulatory Monitoring, Inc.) into two distinct measurements: Zero Crossing Mode (ZCM), which measures the frequency of movement by counting the number of times per epoch that the signal crosses a threshold set near zero; and Proportional Integration Mode (PIM), which calculates the area under the curve for the acceleration signal during each epoch, and therefore discriminates between different intensities of motion. Data were subsequently downloaded using the Action W-2 software package (Ambulatory Monitoring, Inc.). A sample of a patient's actigraph data is provided in Supplementary material 1.

2.4. Additional clinical data

All data related to standard clinical stroke care were prospectively collected in a REDCap database (Vanderbilt University, Nashville, TN) (16, 17). These data included patient demographics, comorbidities, admission NIH Stroke Scale (NIHSS) score, neuroimaging, and other diagnostic testing. ICH-related clinical predictors, including hematoma location, size, and ICH score were adjudicated by two attending neurologists with board certification in neurocritical care and/or vascular neurology until consensus was achieved.

2.5. Data analysis

The task of recognizing episodes of delirium was delineated as a supervised machine learning problem: Given a set of features X derived from patient data, predict delirium status as the dependent outcome variable Y. Because delirium status was measured on a 24-h basis, patient data were preprocessed such that individual features were aggregated into a day-level unit of analysis.

2.6. Actigraph data pre-processing

Raw data for each patient consisted of two parts: raw actigraph measurements, which had minute-to-minute variability, and clinical data, which remained relatively static over the course of each patient's hospitalization (in the case of demographic and stroke-specific data) or over the course of a day (in the case of mechanical ventilation status). Actigraph data for a given 24-h block were partitioned into four groups: full-day (1 to 1 P.M.), morning (6 A.M. to 1 P.M.), afternoon/evening (1 to 10 P.M.), and night-time (10 P.M. to 6 A.M.) epochs. Pre-processing also included normalization of actigraph data prior to classification.

2.7. Actigraph feature extraction

We then aimed to extract clinically meaningful information from the actigraph data to include as features in our delirium prediction models. Figure 1 summarizes the feature extraction process, which culminated in our calculation of two key features from the actigraph data: minutes at rest and within-patient dynamic time warping (DTW).

FIGURE 1
www.frontiersin.org

Figure 1. Feature extraction and classification process. Elements in parentheses were initially explored but ultimately discarded because they did not contribute to higher prediction accuracy.

We defined minutes at rest as the daily proportion of PIM measurements equal to zero in both paretic and non-paretic arms. This feature was chosen due to the importance of psychomotor slowing and inactivity in the diagnosis of delirium (18). It may also provide a helpful estimate of sleep-wake disturbance, a common symptom of delirium (18), though actigraphy likely overestimates actual sleep time in hospital and ICU settings (10).

We also implemented a within-patient control feature calculated as the minimal Euclidean distance of actigraph data with DTW (19). DTW offers a measure of similarity between two temporal sequences that vary in speed. We hypothesized that warping the actigraph signal would facilitate direct comparison of movements caused by routines occurring at regular intervals (e.g., nursing assessments and nursing care), but not necessarily at identical intervals each time, which would address intra-patient variability in our dataset. A higher Euclidean distance suggests a larger difference between the signal in question and the reference. Figure 2 depicts a DTW example.

FIGURE 2
www.frontiersin.org

Figure 2. Dynamic time warping (DTW) example. Original (left) and minimal Euclidean distance warped (right) signals of 2 h of actigraph data.

We considered two separate within-patient control references: using the non-paretic arm as reference, and using the paretic arm in the first day labeled as non-delirious as reference. For consistently delirious patients without non-delirious days, we used the first day of data instead. Our rationale for using within-patient control references is that a patient would serve as their own best baseline to measure changes in movement, and that assessing movement in both arms could function as a surrogate for whole body movement. For instance, increased movement in both paretic and non-paretic arms would suggest externally mediated whole-body movement (e.g., for nursing care), while increased movement in only the non-paretic arm would be more suggestive of patient-initiated limb movement.

2.8. Clinical features

Finally, we included relevant demographics and stroke-specific clinical features in our delirium prediction models. These variables included age, sex, NIHSS scores, and ICH features including hematoma volume, location, and presence of intraventricular hemorrhage, many of which have been described as risk factors for post-stroke delirium in prior studies (20, 21). In addition, we included day-to-day mechanical ventilation status as a dynamic variable in our models, as this was presumed to affect the amount of patient movement (e.g., from sedation).

2.9. Train/test split

To account for limited data set size and high variance among enrolled patients' measurements, we used 500 bootstrapping iterations. During each iteration, data were split into non-overlapping training (80% of patients) and test sets (20% of patients), ensuring that no individual patient's observations were included in both the training and test set. Model training and evaluation were separately performed for each of these 500 random train/test splits. Means and standard deviations across the bootstrapping iterations were reported for metrics including accuracy, balanced accuracy, Receive Operating Characteristic Area Under the Curve (ROC-AUC), and F1-score.

2.10. Machine learning models

A number of alternative machine learning models were trained based on the previously described feature vectors. These included Random Forests, Support Vector Machines (SVM), and Extreme Gradient Boosting (XGBoost). Several filtering techniques were also explore to address the potential impact of patient intervariability, including bandpass and Savitzky-Golay filtering. However, we found no filtering method that improved performance and thus proceeded without any further data preprocessing. We provide the best results obtained by these algorithms, achieved using XGBoost with the following hyperparameters, all of which were tuned via cross-validation on the training set: learning rate 0.03, maximum tree depth 5, minimum child weight 1, subsample fraction 0.8, and column fraction 0.8. Models were trained to detect whether a patient had been delirious at any time during a 24-h period using different subsets of data sources: (1) clinical data only, (2) clinical and actigraph data using the non-paretic arm as reference, and (3) clinical and actigraph data using the first non-delirious day of the paretic arm as reference. We trained our models on a computer with an Intel 8700K CPU and 64 GB of RAM. Using this system, data preparation took ~10 min, and model training and testing took 1–2 min.

3. Results

3.1. Patient characteristics

A total of 40 patients who met eligibility criteria were recruited for this study. A patient flow diagram is provided in Supplementary material 1. To ensure model consistency, we discarded partial actigraph data from the day of enrollment, which also removed the substantial artifact associated with actigraph setup. This led to the exclusion of one patient who was enrolled and discharged prior to recording a full day of actigraph data. As a result, our final cohort comprised 39 patients with a total of 296 days of actigraph monitoring (see Table 1 for baseline characteristics). Among this cohort, 85% of patients (n = 33) had delirium at some point during their hospitalization, including 15 patients who had delirium for the entire duration of monitoring, while 15% of patients (n = 6) never had delirium; 71% (n = 209) of all monitoring days represented days with delirium.

TABLE 1
www.frontiersin.org

Table 1. Baseline characteristics and delirium features for patients with intracerebral hemorrhage (ICH) enrolled in this study.

3.2. Delirium detection

Clinical data alone had low accuracy in detecting delirium on a day-to-day basis (Table 2). However, the addition of actigraph data yielded a significant improvement in accuracy (p < 0.001), with the highest recognition performance reaching an accuracy score of 74%. Using the first non-delirious day as DTW reference resulted in better accuracy than using the non-paretic arm as reference.

TABLE 2
www.frontiersin.org

Table 2. Model performance for same-day delirium detection.

In a post-hoc analysis, we attempted to further filter activity that was presumed to be externally mediated (e.g., from nursing care) by removing certain actigraph data outliers. We defined these outliers as PIM values from the paretic arm that were 10 or more standard deviations higher than the median paretic arm PIM value. However, this procedure did not improve accuracy (accuracy 0.74, balanced accuracy 0.68, F1 0.65, ROC AUC 0.68).

We were also interested in determining which individual features most contributed to model accuracy. This was done by analyzing each feature and the associated information gain it produced, averaged across each run of cross validation. This analysis suggests that night-time DTW actigraph data was an especially important feature, with minutes at rest during afternoon/evening and night-time periods also meaningfully contributing to prediction power (Figure 3).

FIGURE 3
www.frontiersin.org

Figure 3. Individual feature importance for the final model according to XGBoost.

4. Discussion

We found that detecting delirium using actigraphy and machine learning-based analysis was feasible and provided valuable information that significantly improved upon the accuracy of clinical data alone. Given the increasingly recognized impact of delirium on patients with stroke, with consequences ranging from withdrawal of life-sustaining treatment to decreased rates of rehabilitation utilization (22), the early and accurate recognition of delirium in these patients is paramount. Because existing delirium screening tools are unreliable in the setting of severe neurologic deficits, novel tools are needed in the clinical setting, and unconventional methods such as actigraph monitoring may be a promising way to address this gap (21).

The use of machine learning with actigraphy data has been previously implemented for sleep-wake detection with encouraging results (2326), and methods using XGBoost have shown superior performance in classifying actigraph data (24). However, to the best of our knowledge, this is the first study that uses machine learning in combination with actigraphy data to assess delirium status in any patient population.

Theoretically, our study may also have relevance for non-neurologic patients (12, 27), though additional considerations would be required for patients with greater mobility. Although validated delirium screening tools exist in general critical care and hospitalized populations, they can be resource intensive and demand that nurses and other providers be appropriately trained in their use. Automated methods of delirium monitoring could therefore help offset the burden of a strained healthcare staff, especially methods that help monitor for fluctuations in activity and arousal that are characteristic of delirium. Additionally, adjunctive methods of delirium monitoring may also improve overall detection rates in other challenging patient populations, such as those with dementia.

Monitoring patients at night may be especially important in detecting delirium, a concept that is underscored by the significant contribution of night-time actigraph data to the accuracy of our delirium prediction models. Although the high incidence of nocturnal symptoms and sleep-wake disturbances associated with delirium is well known, these symptoms may often go undetected until they reach a point where they become obvious (i.e., severe agitation). It is possible that nocturnal symptoms could be detected sooner via frequent clinical assessments, which are the basis of neurological monitoring in neurocritically ill patients. However, there is increasing controversy regarding the optimal frequency of neuro checks, and it has been hypothesized that overly frequent neurological exams at night may contribute to delirium by leading to sleep fragmentation and overstimulation (28). On the other hand, the relatively unobtrusive nature of wearable sensors may provide valuable complementary information that could help detect delirium during especially high-risk time periods.

Our study is notable for its innovative techniques, including the use of machine-learning to analyze actigraph data and the use of within-patient controls via actigraphs worn on both paretic and non-paretic limbs. However, the study does have several limitations. First, actigraph data are limited by noise and artifacts caused by external movements such as nurse or provider-initiated movements (e.g., during repositioning or clinical examination). Although we excluded artifactual data associated with actigraph initiation from the day of admission and incorporated measurements from both paretic and non-paretic limbs to mitigate potential confounding, we could not definitively filter these externally-mediated movements further. However, their influence may have been relatively modest, as a post-hoc analysis using an outlier filtering method did not result in a meaningful difference in accuracy. Second, because we assessed delirium status only once per day, we may have missed shorter periods of delirium or non-delirium that would have allowed for closer correlation with actigraph data. Finally, our sample size was relatively small and had a class imbalance in favor of delirium-positive days, as many patients were rated as either always (or almost always) delirious or never delirious. Because deep learning requires that voluminous amounts of data be available for optimal results, future studies are needed to analyze data from larger cohorts of patients and further evaluate machine learning-based methods for detecting and predicting delirium. The methods described in this manuscript, paired with a larger dataset, may provide a resulting model that generalizes better and shows less variability in its output metrics.

5. Conclusions

We found that actigraphy in conjunction with machine learning models improves clinical detection of delirium in patients with stroke, thus paving the way to make actigraph-assisted predictions clinically actionable.

Data availability statement

The raw data supporting the conclusions of this article will be made available by the authors, upon reasonable request.

Ethics statement

The studies involving human participants were reviewed and approved by Lifespan Institutional Review Board 2 (ID #1126240). The patients/participants provided their written informed consent to participate in this study.

Author contributions

MR, CE, and RJ: conceptualization and methodology. MR and CE: funding acquisition and supervision. AA, AGA, IP, FR, JF, JZ, HK, SM, JD, CE, and MR: investigation and analysis of data. AA, AGA, CE, and MR: drafting and/or revising significant portions of the manuscript. All authors contributed to the article and approved the submitted version.

Funding

This study was supported by the Rhode Island Foundation, Brown University's Office of the Vice President for Research (OVPR) via a Big Data Collaborative Seed Award, and the Global Individual Fellowship Marie Skłodowska-Curie Action H2020-MSCA-IF-2020 MAESTRO (Grant Number: 101027770).

Conflict of interest

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Publisher's note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

Supplementary material

The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fneur.2023.1135472/full#supplementary-material

References

1. Salluh JI, Wang H, Schneider EB, Nagaraja N, Yenokyan G, Damluji A, et al. Outcome of delirium in critically ill patients: systematic review and meta-analysis. BMJ. (2015) 350:h2538. doi: 10.1136/bmj.h2538

PubMed Abstract | CrossRef Full Text | Google Scholar

2. Reznik ME, Drake J, Margolis SA, Moody S, Murray K, Costa S, et al. Deconstructing poststroke delirium in a prospective cohort of patients with intracerebral hemorrhage. Crit Care Med. (2020) 48:111–8. doi: 10.1097/CCM.0000000000004031

PubMed Abstract | CrossRef Full Text | Google Scholar

3. van Eijk MM, van den Boogaard M, van Marum RJ, Benner P, Eikelenboom P, Honing ML, et al. Routine use of the confusion assessment method for the intensive care unit: a multicenter study. Am J Respir Crit Care Med. (2011) 184:340–4. doi: 10.1164/rccm.201101-0065OC

PubMed Abstract | CrossRef Full Text | Google Scholar

4. Morandi A, Davis D, Bellelli G, Arora RC, Caplan GA, Kamholz B, et al. The diagnosis of delirium superimposed on dementia: an emerging challenge. J Am Med Dir Assoc. (2017) 18:12–8. doi: 10.1016/j.jamda.2016.07.014

PubMed Abstract | CrossRef Full Text | Google Scholar

5. Reznik ME, Daiello LA, Thompson BB, Wendell LC, Mahta A, Potter NS, et al. Fluctuations of consciousness after stroke: associations with the confusion assessment method for the intensive care unit (CAM-ICU) and potential undetected delirium. J Crit Care. (2020) 56:58–62. doi: 10.1016/j.jcrc.2019.12.008

PubMed Abstract | CrossRef Full Text | Google Scholar

6. Reznik ME, Mahta A, Schmidt JM, Frey H-P, Park S, Roh DJ, et al. Duration of agitation, fluctuations of consciousness, and associations with outcome in patients with subarachnoid hemorrhage. Neurocrit Care. (2018) 29:33–9. doi: 10.1007/s12028-017-0491-7

PubMed Abstract | CrossRef Full Text | Google Scholar

7. Ely EW, Truman B, Shintani A, Thomason JW, Wheeler AP, Gordon S, et al. Monitoring sedation status over time in ICU patients: reliability and validity of the Richmond Agitation-Sedation Scale (RASS). JAMA. (2003) 289:2983–91. doi: 10.1001/jama.289.22.2983

PubMed Abstract | CrossRef Full Text | Google Scholar

8. Meagher DJ, Moran M, Raju B, Gibbons D, Donnelly S, Saunders J, et al. Motor symptoms in 100 patients with delirium versus control subjects: comparison of subtyping methods. Psychosomatics. (2008) 49:300–8. doi: 10.1176/appi.psy.49.4.300

PubMed Abstract | CrossRef Full Text | Google Scholar

9. Sadeh A. The role and validity of actigraphy in sleep medicine: an update. Sleep Med Rev. (2011) 15:259–67. doi: 10.1016/j.smrv.2010.10.001

PubMed Abstract | CrossRef Full Text | Google Scholar

10. Schwab KE, To AQ, Chang J, Ronish B, Needham DM, Martin JL, et al. Actigraphy to measure physical activity in the intensive care unit: a systematic review. J Intensive Care Med. (2020) 35:1323–31. doi: 10.1177/0885066619863654

PubMed Abstract | CrossRef Full Text | Google Scholar

11. Schwab KE, Ronish B, Needham DM, To AQ, Martin JL, Kamdar BB. Actigraphy to evaluate sleep in the intensive care unit. A systematic review. Ann Am Thorac Soc. (2018) 15:1075–82. doi: 10.1513/AnnalsATS.201801-004OC

PubMed Abstract | CrossRef Full Text | Google Scholar

12. Osse RJ, Tulen JH, Hengeveld MW, Bogers AJ. Screening methods for delirium: early diagnosis by means of objective quantification of motor activity patterns using wrist-actigraphy. Interact Cardiovasc Thorac Surg. (2009) 8:344–8. doi: 10.1510/icvts.2008.192278

PubMed Abstract | CrossRef Full Text | Google Scholar

13. Eeles E, Tahir TA, Johansen A, Bisson JI, Hubbard RE. Comparison of clinical assessment and actigraphy in the characterization of delirium. J Psychosom Res. (2009) 67:103–4. doi: 10.1016/j.jpsychores.2009.02.003

PubMed Abstract | CrossRef Full Text | Google Scholar

14. Maybrier HR, King CR, Crawford AE, Mickle AM, Emmert DA, Wildes TS, et al. Early postoperative actigraphy poorly predicts hypoactive delirium. J Clin Sleep Med. (2019) 15:79–87. doi: 10.5664/jcsm.7576

PubMed Abstract | CrossRef Full Text | Google Scholar

15. Diagnostic and Statistical Manual of Mental Disorders: DSM-5. 5th ed. Arlington, VA: American Psychiatric Association (2013).

Google Scholar

16. Harris PA, Taylor R, Thielke R, Payne J, Gonzalez N, Conde JG. Research electronic data capture (REDCap)—A metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform. (2009) 42:377–81. doi: 10.1016/j.jbi.2008.08.010

PubMed Abstract | CrossRef Full Text | Google Scholar

17. Harris PA, Taylor R, Minor BL, Elliott V, Fernandez M, O'Neal L, et al. The REDCap consortium: building an international community of software platform partners. J Biomed Inform. (2019) 95:103208. doi: 10.1016/j.jbi.2019.103208

PubMed Abstract | CrossRef Full Text | Google Scholar

18. Meagher DJ, Moran M, Raju B, Gibbons D, Donnelly S, Saunders J, et al. Phenomenology of delirium: assessment of 100 adult cases using standardised measures. Br J Psychiatry. (2007) 190:135–41. doi: 10.1192/bjp.bp.106.023911

PubMed Abstract | CrossRef Full Text | Google Scholar

19. Berndt DJ, Clifford J. Using Dynamic Time Warping to Find Patterns in Time Series. Seattle, WA: KDD Workshop (1994).

Google Scholar

20. Oldenbeuving AW, de Kort PL, van Eck van der Sluijs JF, Kappelle LJ, Roks G. An early prediction of delirium in the acute phase after stroke. J Neurol Neurosurg Psychiatry. (2014) 85:431–4. doi: 10.1136/jnnp-2013-304920

PubMed Abstract | CrossRef Full Text | Google Scholar

21. Reznik ME, Margolis SA, Mahta A, Wendell LC, Thompson BB, Stretz C, et al. Impact of delirium on outcomes after intracerebral hemorrhage. Stroke. (2021) 53:505–13. doi: 10.1161/STROKEAHA.120.034023

PubMed Abstract | CrossRef Full Text | Google Scholar

22. Reznik ME, Moody S, Murray K, Costa S, Grory BM, Madsen TE, et al. The impact of delirium on withdrawal of life-sustaining treatment after intracerebral hemorrhage. Neurology. (2020) 95:e2727–35. doi: 10.1212/WNL.0000000000010738

PubMed Abstract | CrossRef Full Text | Google Scholar

23. Mikkelsen KB, Ebajemito JK, Bonmati-Carrion MA, Santhi N, Revell VL, Atzori G, et al. Machine-learning-derived sleep–wake staging from around-the-ear electroencephalogram outperforms manual scoring and actigraphy. J Sleep Res. (2019) 28:e12786. doi: 10.1111/jsr.12786

PubMed Abstract | CrossRef Full Text | Google Scholar

24. Khademi A, El-Manzalawy Y, Master L, Buxton OM, Honavar VG. Personalized sleep parameters estimation from actigraphy: a machine learning approach. Nat Sci Sleep. (2019) 2019:387–99. doi: 10.2147/NSS.S220716

PubMed Abstract | CrossRef Full Text | Google Scholar

25. Kuzik N, Spence JC, Carson V. Machine learning sleep duration classification in preschoolers using waist-worn actigraphs. Sleep Med. (2021) 78:141–8. doi: 10.1016/j.sleep.2020.12.019

PubMed Abstract | CrossRef Full Text | Google Scholar

26. Li X, Zhang Y, Jiang F, Zhao H. A novel machine learning unsupervised algorithm for sleep/wake identification using actigraphy. Chronobiol Int. (2020) 37:1002–15. doi: 10.1080/07420528.2020.1754848

PubMed Abstract | CrossRef Full Text | Google Scholar

27. Jaiswal SJ, Bagsic SRS, Takata E, Kamdar BB, Ancoli-Israel S, Owens RL. Actigraphy-based sleep and activity measurements in intensive care unit patients randomized to ramelteon or placebo for delirium prevention. Sci Rep. (2023) 13:1450. doi: 10.1038/s41598-023-28095-0

PubMed Abstract | CrossRef Full Text | Google Scholar

28. LaBuzetta JN, Kamdar BB, Malhotra A. Reassessing hourly neurochecks. J Clin Neurosci. (2023) 110:71–3. doi: 10.1016/j.jocn.2023.02.009

PubMed Abstract | CrossRef Full Text | Google Scholar

Keywords: delirium, neurocritical care, stroke, intracerebral hemorrhage, actigraphy, machine learning, wearable electronic devices

Citation: Ahmed A, Garcia-Agundez A, Petrovic I, Radaei F, Fife J, Zhou J, Karas H, Moody S, Drake J, Jones RN, Eickhoff C and Reznik ME (2023) Delirium detection using wearable sensors and machine learning in patients with intracerebral hemorrhage. Front. Neurol. 14:1135472. doi: 10.3389/fneur.2023.1135472

Received: 31 December 2022; Accepted: 24 April 2023;
Published: 09 June 2023.

Edited by:

Sim Kuan Goh, Xiamen University Malaysia, Malaysia

Reviewed by:

Hipólito Nzwalo, University of Algarve, Portugal
Chow Khuen Chan, University of Malaya, Malaysia

Copyright © 2023 Ahmed, Garcia-Agundez, Petrovic, Radaei, Fife, Zhou, Karas, Moody, Drake, Jones, Eickhoff and Reznik. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Carsten Eickhoff, carsten@brown.edu; Michael E. Reznik, michael_reznik@brown.edu

These authors have contributed equally to this work

These authors have contributed equally to this work and share senior authorship

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.