Abstract
Meningioangiomatosis (MA) is a rare malformation or hamartomatous lesion in the central nervous system, characterized by a plaque-like mass within the leptomeninges and cerebral cortex. An even rarer condition is MA complicated with meningiomas. We herein report a case of meningioma associated with MA that might be erroneously interpreted as a higher-grade lesion or an invasion by preoperative radiologic and postoperative histological examinations.
Introduction
Meningioangiomatosis (MA) features vascular proliferation and perivascular cell growth (1). However, the pathogenesis of MA remains unclarified, although it was originally described as a condition associated with neurofibromatosis (NF)-2 (2). The principal hypotheses include hamartomatous lesions, direct invasion of malignant meningiomas, and cortical vascular malformations (1). Meningiomas combined with MA (MA-M) are extremely rare (3). MA-M may often show similar radiologic and histological results to an invasive meningioma, which presents challenges to the treatment (4). To further the understanding of this disorder, we present a case of MA-M in a 28 years-old man and discuss its clinical presentation and histopathologic characteristics.
Case presentation
A 28 years-old man presented with maxillofacial discomfort and headache for 2 weeks, and then visited a regional hospital for consultation. Neurologic and physical exams showed he was both mentally and physically healthy. No past medical history was reported. Computer tomography (CT) indicated a high-density nodule in the right frontal lobe. Magnetic resonance imaging (MRI) with contrast revealed a heterogeneously intradural lesion measuring 19 × 17 cm in the right frontotemporal lobe (Figure 1). A meningioma or an oligodendroglioma was suspected.
Figure 1
The patient underwent the conventional right pterional craniotomy, which revealed an ill-defined mass with a soft grayish-white surface. There were many calcifications in the middle, and the surrounding tissue was slightly edematous. The tumor tissue was completely resected under the microscope.
Microscopically, the lesion was composed of meningothelial and spindle cells, which formed small whorls. In the whorl center, psammoma bodies were observed. There was no evidence of necrosis or mitotic activity. The histopathological features of the lesion were consistent with those of a transitional meningioma. In the adjacent cerebral parenchyma to the lesion, significant proliferation of meningothelial cells surrounding the small blood vessels was detected (Figures 2A,B). This was the same as the characteristic morphology of MA. Immunohistochemical analysis revealed that tumor cells of the meningioma were positive for vimentin, somatostatin receptor (SSTR)-2 (Figure 2C), epithelial membrane antigen (EMA), and progesterone receptor (PR). The perivascular fibroblast-like spindle cells were positive for vimentin and SSTR2 but lacked immunoreactivity for EMA and GFAP (Figure 2D). Ki-67 (MIB-1) index was smaller than 2% in all areas. Mutational analysis of NF2 was negative.
Figure 2
Based on the above results, the patient was finally diagnosed with a transitional meningioma (WHO grade 1) associated with MA. After surgery, the patient was followed up for 8 months without receiving any adjuvant radiotherapy or chemotherapy. During this period, the patient was disease-free.
Literature review
All English literature about MA-M published on PubMed was reviewed, and the clinical pathology information on sex, age, location of the lesion, clinical presentation, histopathological type of the meningioma, and clinical outcomes was obtained. A total of 62 cases of MA-M were included. Clinical information on these cases and the present case is detailed in Table 1 (5–25).
Table 1
| Author (year) | N/sex | Age | Presentation | Location | Histopathologic type of meningioma | Outcome |
|---|---|---|---|---|---|---|
| Auer et al. (5) | 1/M | 15 | Subarachnoid hemorrhage | Frontal lobe | Fibrous | Died from complications |
| Louw et al. (6) | 2/M | 15–33 | Subarachnoid hemorrhage, headache | Frontal lobe | Fibrous, transitional | NA |
| Blumenthal et al. (7) | 1/M | 0.9 | Seizure | Frontal lobe | Transitional | NR |
| Giangaspero et al. (8) | 2/M | 9–28 | Asymptomatic, seizure | Temporal, frontal lobe | Transitional | NR |
| Mut et al. (9) | 1/F | 20 | Seizure | Temporal lobe | Transitional | NR |
| Sinkre et al. (10) | 1/M | 8 | Headache | Frontal lobe | Atypical | NR |
| Kim et al. (11, 12) | 6/M, 2/F | 3–19 | Seizure, headache | Frontoparietal, temporal, frontal, parieto-occipital lobe | Fibrous, transitional, meningothelial, psammomatous | NR, recurrence (1 case) |
| Iezza et al. (13) | 1/M | 33 | Seizure | Frontal lobe | Transitional | NA |
| Kuchelmeister et al. (14) | 1/M | 58 | Headache and forgetfulness | Frontal lobe | Microcystic | NR |
| Perry et al. (3) | 8/M, 2/F | 0.8–35 | NA | Frontal, temporal lobe | Transitional, meningothelial, atypical | NA |
| Deb et al. (15) | 1/F | 1.5 | Seizure | Temporal lobe | Transitional | NR |
| Saad et al. (16) | 1/F | 3 | Seizure | Frontal lobe | NA | NA |
| Shi et al. (17) | 1/F | 50 | Headache and dizziness | Temporal lobe | Meningothelial | NR |
| Chen et al. (18) | 1/M | 34 | Numbness and weakness of lower extremity | Frontoparietal lobe | Atypical | NR |
| Cui et al. (19) | 1/M | 33 | Seizure | Frontal lobe | Transitional | NR |
| Zhang et al. (20) | 7/M | 3–32 | Headache, seizure, diabetes insipidus | Frontal, temporal, parietal lobe, corpus callosum, third ventricle | Transitional, fibrous, psammomatous | NR, died (1 case) |
| Diao et al. (21) | 1/F | 16 | Seizure | Parieto-occipital lobe | Meningothelial | NR |
| Galloway et al. (22) | 1/M | 1.5 | Seizure | Temporal lobe | Rhabdoid | NR |
| Hassan et al. (4) | 1/M | 11 | Headache and diplopia | Temporal lobe | Atypical | NR |
| Dono et al. (23) | 1/F, 1/M | 14–26 | Seizure | Temporal lobe | NA | NR |
| Liu et al. (24) | 1/M | 8 | Dizziness and seizure | Parietal lobe | Fibrous | NR |
| Zhang et al. (25) | 9/M, 7/F | 3–46 | Seizure, headache, nausea, organic psycho-syndrome, hyperhidrosis and hearing loss, facial paralysis, polyuria | Frontal, parietal, temporal lobe, sphenoid ridge, anterior cranial fossa, callosum, third ventricle | Fibrous, transitional, meningothelial, atypical, metaplastic | NR, died (1 case) |
| Present | 1/M | 28 | Maxillofacial discomfort and headache | Frontotemporal lobe | Transitional | NR |
Case reports and series of MA-M in the English literature.
NR, no recurrence; NA, not available.
Discussion
MA has been described to occur together with meningiomas, oligodendrogliomas, schwannomas, encephaloceles, and vascular malformations in rare cases (3). Among these co-morbidities, MA associated with meningiomas is the commonest (19). At the time of writing, we had found 63 cases of MA-M including the present case in all the English literature reviewed (5–25). There were 46 men and 17 women (male to female ratio, 2.7:1). MA-M tended to occur in young patients with a mean age of 17.5 years (0.8 to 58 years). The most common symptom were seizures (31 cases) and headache (11 cases). The lesion mainly affected the frontal lobe (23 cases) and temporal lobe (18 cases).
Radiologically, pre-surgical diagnosis of MA-M is challenging due to its variable appearances. MRI is usually the imaging modality of choice, and MA-M lesions typically appear hypo-or iso-intense on T1-weighted images and hyperintense on T2-weighted images (24). MRI results showed that the majority of the MA-M cases had intracortical non-enhanced lesions without dural attachment.
Transitional (23 cases) and fibroblastic (14 cases) meningiomas were the predominant subtypes in the MA-M patients. Additionally, there were also 8 atypical, 7 meningothelial, 4 metaplastic, 2 psammomatous, 1 microcystic, and 1 rhabdoid subtypes. A clear transition zone between neoplastic meningiomas and MA was not found. Similar to MA, the adjacent cerebral parenchyma was also histopathologically characterized by cortical meningovascular proliferation and the perivascular spread of meningothelial and fibroblast-like cells along the Virchow–Robin spaces (19). Neither necrosis nor mitotic activity was detected. Immunohistochemistry was of small diagnostic value, as staining patterns were inconsistent among cases (25). The Ki-67 labelling index values ranged from <1% to 15%, most of which were less than 1% (12). The diagnosis and classification of meningioma rely on analyzing both its histopathological features and genetic alterations (26). The WHO grade of MA-A is determined by the grade of the accompanying meningioma.
The pathogenesis of MA requires further investigation. A few hypotheses on MA pathogenesis have been proposed, including developmental and hamartomatous lesions, cortical vascular malformations, and direct invasion into the brain parenchyma by a meningioma (1). Among these hypotheses, the hamartomatous or cortical dysplastic etiology were favored based on the lack of significant proliferative activity and benign clinical course in most MA cases.
MA-M can be easily mistaken for invasive meningiomas because of its feature of cortical invasion (4). Meningothelial and vascular proliferation along the Virchow–Robin spaces do not actually represent parenchymal invasion and have no direct relationship with the risk of recurrence (1). True invasion takes place when tumor cells break through the pia mater to invade the cerebral parenchyma. Generally, there is a serrated irregular outer border intermixed with the cerebral cortex in invasive meningiomas. Unlike invasive meningiomas, MA-M is benign, lacking such features as atypia, mitoses, and necrosis, with an excessively low value of Ki-67 labelling index.
Surgery resection is the primary treatment for MA-M and the surgical approach is similar to that for invasive meningioma. Incomplete resection of MA-M might pose a risk of recurrence or epilepsy. Surgical resection is the recommended treatment for recurrent tumors that have undergone prior excision, with adjuvant radiotherapy being considered in selected cases (27). None of the studied patients received radiotherapy and chemotherapy after gross-total resection. Follow-up information of 49 cases was available, and the follow-up time ranged from 5 to 113 months. At the end of the follow-up, 45 patients were alive with no evidence of disease, 1 patient suffered recurrence (11), and 3 patients died of operative complications or other diseases (12, 20, 25).
Due to the good prognosis of MA-M, more precise diagnosis for these rare cases is important, which provides guidance for clinical management. Preclinical models of meningioma may provide an ideal platform for testing the molecular mechanisms of tumor development and targeted therapies (28). Advancements in artificial intelligence and radiomics have facilitated the characterization of meningiomas, providing critical information for this disease.
Funding
This study was supported by the Medical and Health Research Project of Zhejiang Province (2022KY1185) and Ningbo Leading Medical & Health Discipline (2022-F30).
Publisher’s note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
Statements
Data availability statement
The original contributions presented in the study are included in the article/supplementary material, further inquiries can be directed to the corresponding author.
Ethics statement
The studies involving human participants were reviewed and approved by Ningbo Clinical Pathology Diagnosis Center. The patients/participants provided their written informed consent to participate in this study. Written informed consent was obtained from the individual(s) for the publication of any potentially identifiable images or data included in this article.
Author contributions
RG: collection of the data and drafting the manuscript. JY and XY: data analysis and statistical analysis. JW: critical revisions of the manuscript. All authors contributed to the article and approved the submitted version.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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Summary
Keywords
meningioangiomatosis, meningioma, invasive meningioma, pathology, neurology
Citation
Ge R, Yang J, Yin X and Wang J (2023) Case report: Meningioma associated with meningioangiomatosis mimicking invasive meningioma. Front. Neurol. 14:1200827. doi: 10.3389/fneur.2023.1200827
Received
05 April 2023
Accepted
15 June 2023
Published
28 June 2023
Volume
14 - 2023
Edited by
Brandon Peter Lucke-Wold, University of Florida, United States
Reviewed by
Ilaria Bove, Seconda Università Degli Studi Di Napoli, Italy; Andrea Carai, Bambino Gesù Children’s Hospital (IRCCS), Italy
Updates
Copyright
© 2023 Ge, Yang, Yin and Wang.
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*Correspondence: Jingya Wang, 373508383@qq.com
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.