ORIGINAL RESEARCH article

Front. Neurol.

Sec. Endovascular and Interventional Neurology

Volume 16 - 2025 | doi: 10.3389/fneur.2025.1452495

This article is part of the Research TopicCarotid Atherosclerosis: Molecular Mechanisms, Diagnosis, Prognosis And Potential TherapiesView all 9 articles

Impact of Carotid Artery Revascularization on Cognitive Function: A Study of Symptomatic and Asymptomatic Cases

Provisionally accepted
Sensen WuSensen Wu1Yachan NingYachan Ning1,2Wang HuiWang Hui1Dikang PanDikang Pan1Julong GuoJulong Guo1Cong WangCong Wang1Chunmei WangChunmei Wang1,2Yongquan GuYongquan Gu1*Lianrui GuoLianrui Guo1*
  • 1Department of Vascular Surgery, Xuanwu Hospital, Capital Medical University, Beijing, China
  • 2Department of Intensive Care Medicine, Xuanwu Hospital, Capital Medical University, Beijing, Beijing Municipality, China

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Objective: To investigate and compare changes in cognitive function following revascularization between patients with symptomatic and asymptomatic carotid stenosis. Methods: From April 2019 to April 2022, patients carotid artery stenosis who were treated with carotid endarterectomy (CEA) or carotid artery stenting (CAS) were recruited for this study. The Montreal Cognitive Assessment (MoCA) instrument was used to evaluate cognitive function preoperatively and at 3, 6, and 12 months postoperatively. Patients were divided into two groups based on the neurological symptoms, repeated measures ANOVA was used for comparisons. Results: A total of 89 patients who met the criteria were enrolled and completed 1-year follow-up, divided into symptomatic group (32 patients) and asymptomatic group (57 patients). Baseline data showed no significant differences in clinical characteristics between the two groups. At 3, 6, and 12 months after carotid revascularization, the total MoCA and delayed recall scores for both groups showed significant increases compared to baseline levels. In patients with asymptomatic, attention also showed improvement at 3, 6 months compared to baseline (p<0.05). Conclusion: Carotid revascularization has a positive impact on cognitive function improvement, particularly in delayed recall and attention.

Keywords: Cognition, Carotid artery revascularization, Carotid endarterectomy, Carotid artery stenting, Symptomatic

Received: 24 Jun 2024; Accepted: 15 May 2025.

Copyright: © 2025 Wu, Ning, Hui, Pan, Guo, Wang, Wang, Gu and Guo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Yongquan Gu, Department of Vascular Surgery, Xuanwu Hospital, Capital Medical University, Beijing, China
Lianrui Guo, Department of Vascular Surgery, Xuanwu Hospital, Capital Medical University, Beijing, China

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