SYSTEMATIC REVIEW article
Front. Neurol.
Sec. Neurorehabilitation
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1455545
This article is part of the Research TopicReviews in Acute Stroke and Interventional Therapies 2023View all 7 articles
Bibliometric analysis of research trends on hyperbaric oxygen therapy in stroke from 2000 to 2022
Provisionally accepted
- 1Department of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, China
- 2Key Laboratory of Rehabilitation Medicine in Sichuan Province, West China Hospital, Sichuan University, Chengdu, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Background: Stroke primarily results from the interruption of cerebral blood flow. Hyperbaric oxygen therapy (HBOT), a noninvasive and promising therapeutic intervention, has been widely used to treat various ischemic and hypoxic conditions. Over the past two decades, extensive research has demonstrated HBOT's efficacy in reducing cerebral infarct volume, establishing it as a viable neuroprotective strategy. Given these findings, this study employs bibliometric analysis to explore emerging trends and key research foci in HBOT applications for stroke management. Method: We performed a systematic literature search on hyperbaric oxygen therapy (HBOT) and stroke using the Web of Science Core Collection (WoSCC) database, specifically the Science Citation Index Expanded (SCI-Expanded). The search was restricted to English-language articles and reviews published between January 2000 and December 2022. Data retrieval, screening, and analysis were conducted in June 2023. Results: A total of 323 publications were identified, demonstrating annual fluctuations in research output. The United States dominated HBOT-related stroke research in both publication volume and scientific impact. Shai Efrati emerged as the most prolific author in this field, while the Sackler Faculty of Medicine at Tel Aviv University was the most influential institution. The journal Stroke published the highest number of HBOT-related stroke studies. Co-citation analysis revealed "cognitive function" as the primary research focus in HBOT applications for stroke. Conclusion: This bibliometric analysis investigated the current research landscape, trends, and emerging priorities in hyperbaric oxygen therapy (HBOT) applications for stroke. The primary research focus centered on HBOT's therapeutic potential for cognitive function enhancement and chronic-phase post-stroke treatment.
Keywords: hyperbaric oxygen therapy, bibliometric analysis, HBOT, stroke. 1 Introduction, Trends
Received: 27 Jun 2024; Accepted: 12 May 2025.
Copyright: © 2025 Zhou, Chen, Li, Luo, Song, You, Ma and Huang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Cheng Huang, Department of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.