ORIGINAL RESEARCH article
Front. Neurol.
Sec. Endovascular and Interventional Neurology
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1490127
Relationship between first pass effect NLR and PLR in mechanical thrombectomy for acute anterior circulation large-vessel occlusion
Provisionally accepted
- 1Department of Neurosurgery, Liaocheng People’s Hospital, Liaocheng, Shandong Province, China
- 2School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong Province, China
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The study investigated the correlation between the neutrophil-lymphocyte ratio (NLR) and the platelet-lymphocyte ratio (PLR) concerning the first-pass effect (FPE) observed during mechanical thrombectomy subsequent to acute ischemic stroke (AIS).Patients diagnosed with AIS in the anterior circulation, who underwent mechanical thrombectomy between January 2020 and December 2022, were assessed. Various data were collected, including blood cell counts, general information, relevant surgical and clinical details, and functional outcomes determined by the Modified Rankin Scale (MRS) score ≤ 2 at three months.Logistic regression was utilized to identify independent factors predicting the first-pass effect (FPE) and to explore the associations between FPE and the NLR and PLR. Critical NLR and PLR values were examined using Receiver-operating characteristics (ROC) curves.Results: A total of 233 patients were enrolled and categorized into either the FPE or multiple pass effect (MPE) groups based on the success of the initial thrombectomy. The FPE group showed significant distinctions compared to the MPE group in both NLR and PLR levels: NLR (3.63 vs. 4.90, p<0.001), PLR (134.92 vs. 164.77, p=0.001). Both univariate and multivariate regression analyses demonstrated the independent predictive ability of NLR and PLR for assessing the risk of FPE during mechanical thrombectomy, with NLR (Adjusted Odds ratio (OR) 0.764; 95% CI 0.665-0.878, p=0.0010.773, 95% CI 0.672-0.888, p=0.001) and PLR (Adjusted OR 0.993; 95% CI 0.989-0.998, p=0.0020.995, 95% CI 0.990-0.999, p=0.016). Moreover, the ROC curves delineated critical threshold values of 4.34 and 148.03 for NLR and PLR, respectively.The increase of NLR and PLR may be related to the failure of FPE. Elevated NLR and PLR can independently predict the risk of first-pass mechanical thrombectomy failure.
Keywords: Mechanical thrombectomy, first pass recanalization, Neutrophil-lymphocyte ratio, Platelet-lymphocyte ratio, Acute cerebral artery occlusion
Received: 18 Mar 2025; Accepted: 13 Jun 2025.
Copyright: © 2025 Lu, Wang, Xv, Lv, Zhang, Wang and Hao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jiheng Hao, Department of Neurosurgery, Liaocheng People’s Hospital, Liaocheng, Shandong Province, China
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