HYPOTHESIS AND THEORY article
Front. Neurol.
Sec. Neuromuscular Disorders and Peripheral Neuropathies
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1508176
Hypothesis Paper: High prevalence of Tinel sign in hypermobile Ehlers-Danlos syndrome
Provisionally accepted
- 1George Washington University, Washington, D.C., United States
- 2Mayo Clinic Florida, Jacksonville, Florida, United States
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Ehlers-Danlos syndromes (EDS) encompass a group of genetic connective tissue disorders that affect the structure and function of proteins and enzymes that provide stability to the body. The hypermobile subtype of EDS (hEDS) is the most common and is characterized by joint hypermobility, skin hyperextensibility, and widespread musculoskeletal pain. Neuropathic symptoms, including pain, numbness, tingling, and weakness, are increasingly recognized in this population. This paper proposes a study to test the hypothesis that hEDS individuals will have a higher prevalence of positive Tinel signs compared to controls, indicating heightened sensitivity to nerve irritation or compression in hEDS that can guide better diagnosis and treatment.
Keywords: Tinel sign, hypermobile Ehlers-Danlos syndromes, Cubital Tunnel Syndrome, Carpal Tunnel Syndrome, Neuralgia, Neuropathy
Received: 08 Oct 2024; Accepted: 15 Aug 2025.
Copyright: © 2025 Hashemi, MD F.A.C.S. and Knight. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Shahreyar Shar Hashemi, MD F.A.C.S., George Washington University, Washington, D.C., United States
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