REVIEW article
Front. Neurol.
Sec. Neuromuscular Disorders and Peripheral Neuropathies
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1521941
Selection of Sciatic Nerve Injury Models: Implications for Pathogenesis and Treatment
Provisionally accepted
- Hunan University of Chinese Medicine, Changsha, Anhui Province, China
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Sciatic nerve injury is one of the most frequent peripheral nerve injuries in the world.The loss of motor and sensory function, along with chronic pain caused by sciatic nerve injury, significantly impacts patients' quality of life. However, there are numerous restrictions on in vitro studies on the regeneration and healing of sciatic nerve damage. In contrast, in vivo studies can more accurately mimic clinical pathology through a variety of experimental animal models and a variety of modeling methods. However, the selection of different models has its focus, so this paper reviews the selection of experimental animals, modeling methods, and common treatment protocols. The advantages and disadvantages of each species are discussed, and the modeling methods of five common sciatic nerve injury models,
Keywords: Sciatic nerve injury, Animal Models, chronic constriction injury, Partial sciatic nerve ligation, Sciatic nerve crush injury, Sciatic nerve transection, Treatments of sciatic nerve sciatic nerve injury"
Received: 05 Nov 2024; Accepted: 17 Apr 2025.
Copyright: © 2025 Zhou, Zhang, Xian, Ning, Lu, Liu and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Qianyan Liu, Hunan University of Chinese Medicine, Changsha, 410208, Anhui Province, China
Mi Liu, Hunan University of Chinese Medicine, Changsha, 410208, Anhui Province, China
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