SYSTEMATIC REVIEW article
Front. Neurol.
Sec. Neuroepidemiology
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1525481
Trends in Mendelian Randomization in Neurological Disease Research: A Bibliometric Analysis
Provisionally accepted
- 1First Affiliated Hospital of Xinjiang Medical University, Urumqi, China
- 2College of Health Management, Xinjiang Medical University, Urumqi, China
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Bibliometric analysis (BA) was used in this study to examine the current state and trends of Mendelian randomization (MR) in neurological disease research. The Web of Science database was searched between 1 January 2014 and 1 September 2024 to retrieve relevant literature. The volume of publications, research themes, collaborative networks, and geographical distribution were studied quantitatively. A keyword co-occurrence analysis identified prominent research hotspots, including stroke, cardiovascular disease, and genome-wide association studies. Furthermore, highly cited literature underscored the potential of MR to elucidate causal relationships between genetic variants and health outcomes. International collaborative networks indicate that China, the United Kingdom, and the United States are the most engaged in collaborative efforts within this domain. The findings suggest that MR methods hold significant potential for applications in the investigation of neurological disorders, highlighting the necessity of international collaboration to foster scientific advancement. Future research should prioritize enhancing interdisciplinary collaboration and conducting comprehensive explorations of disease mechanisms to aid in prevention and treatment.
Keywords: Neurological Disease, Mendelian randomization, bibliometric analysis, review, Research trends
Received: 01 Dec 2024; Accepted: 30 Jun 2025.
Copyright: © 2025 Yin, Zakeer, Ma, Zhao, Maimaiti and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Shengnan Yin, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China
Zekun Ma, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China
Zengliang Wang, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China
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