REVIEW article
Front. Neurol.
Sec. Neurocritical and Neurohospitalist Care
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1526021
This article is part of the Research TopicMechanisms and Interventions for Post-Operative Neurocognitive Disorder and Sleep DisruptionsView all 13 articles
Perioperative Neurocognitive Disorders: A Comprehensive Review of Terminology, Clinical Implications, and Future Research Directions
Provisionally accepted
- 1Jilin University, Changchun, China
- 2Department of Anesthesiology, The Third Hospital of Jilin University, Changchun, Hebei Province, China
- 3School of Basic Medicine, Jilin Medical University, Jilin, Jilin, China
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Perioperative neurocognitive disorders (PNDs) encompass a spectrum of cognitive impairments that may affect patients before, during, or after surgical procedures, with significant implications for patient outcomes, and healthcare expenditures. This comprehensive review examines the evolution of PND terminology, clinical manifestations, diagnostic criteria, incidence rates, risk factors, underlying mechanisms, preventive measures, management strategies, and future research directions. The authors emphasize the importance of early diagnosis and intervention to enhance postoperative recovery and underscore the necessity of a multidisciplinary approach to patient care.
Keywords: Perioperative neurocognitive disorders, postoperative cognitive dysfunction, perioperative cognitive impairment, surgical outcomes, Delirium, Postoperative Care
Received: 12 Nov 2024; Accepted: 21 Apr 2025.
Copyright: © 2025 Ren, Zhang, Chen, Li, Zhao and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xuli Ren, Jilin University, Changchun, China
Guoqing Zhao, Department of Anesthesiology, The Third Hospital of Jilin University, Changchun, Hebei Province, China
Fang Wang, School of Basic Medicine, Jilin Medical University, Jilin, Jilin, China
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