ORIGINAL RESEARCH article
Front. Neurol.
Sec. Endovascular and Interventional Neurology
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1528168
This article is part of the Research TopicAdvances in the Understanding, Diagnosis, and Management of Intracranial and Extracranial Arterial DissectionsView all 7 articles
Safety and Efficacy of Intravenous Thrombolysis for Acute Ischemic Stroke Secondary to Intracranial Vertebrobasilar Artery Dissection
Provisionally accepted
- 1The Fourth People's Hospital Affiliated to Tongji University, Shanghai, China, Shanghai, China
- 2Department of Cardiovascular Diseases, Changhai Hospital, Second Military Medical University, Shanghai, China
- 3Department of Neurosurgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China
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Objective: The safety and effectiveness of thrombolysis in patients with intracranial artery dissection (IAD) are still controversial. This study aims to assess the safety and efficacy of intravenous thrombolysis (IVT) in patients with intracranial vertebrobasilar artery dissection (i-VBAD)related acute ischemic stroke (AIS).Methods: A retrospective review of 32 patients admitted to our Neurovascular Center between January 2016 and June 2021 with AIS due to i-VBAD was conducted. Patients were identified and divided into IVT group (n=8) and non-IVT group (n=24) receiving standard antithrombotic therapy.Results: The mean age of the 32 patients was 49.28±15.6 years, with a male predominance (87.5%). All patients presented with clinical manifestations consistent with posterior circulation infarct. Patients in the IVT group were significantly older than those in non-IVT group (58.88 vs. 46.08 years, P=0.043) and had a higher prevalence of diabetes mellitus (50.0% vs. 8.3%, P=0.023). No intracranial hemorrhage was observed in of the eight patients in IVT group. An excellent functional outcome, defined as an modified Rankin Scale score of 0–1, was achieved in all eight patients in the IVT group (100%) compared to 15 of the 24 patients in the non-IVT group (62.5%, P=0.070). Although the difference did not reach statistical significance, the trend suggested a potential benefit of IVT in this patient population.Conclusion: IVT appears safe with no hemorrhagic complications in i-VBAD patients. It may offer better functional outcomes compared to standard therapy. Larger, prospective, multicenter studies are needed for definitive validation.
Keywords: Acute ischemic stroke, vertebrobasilar artery dissection, intravenous thrombolysis, HR-MRI, Safety and efficacy
Received: 14 Nov 2024; Accepted: 15 Apr 2025.
Copyright: © 2025 Wang, Liu, Lin, Deng, Zhao and Wu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Kaijun Zhao, Department of Neurosurgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China
Tao Wu, The Fourth People's Hospital Affiliated to Tongji University, Shanghai, China, Shanghai, China
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