ORIGINAL RESEARCH article
Front. Neurol.
Sec. Sleep Disorders
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1531241
This article is part of the Research TopicSleep and Cardiovascular DiseaseView all articles
Study on the Relationship between Sleep-Wake States and Prognosis in Patients with Intracranial Arterial Stenosis and Ischemic Stroke
Provisionally accepted
- Kailuan General Hospital, Tangshan, Hebei Province, China
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Objective: To evaluate the influence of the sleep-wake state on the prognosis of patients with ischemic stroke.Methods: Consecutive patients with intracranial ischemic stroke due to arterial stenosis were included (198 cases). The control group consisted of contemporaneous patients without cerebrovascular stenosis or any diagnosed cerebrovascular disease（77 cases）.Collect the following variables of the patients, including the total recording time during the day and night, total sleep time, sleep latency, rapid eye movement (REM) sleep latency, wake time after falling asleep, light sleep stage (N1, N2 stage), deep sleep stage (N3 stage), and non-rapid eye movement (non-rapid eye movement) (NREM) sleep stage, rapid eye movement (REM) sleep stage, and stroke topography (anterior circulation and posterior circulation ischemic stroke). The primary outcome was the functional status at discharge, evaluated using the modified Rankin Scale (mRS) : good prognosis (mRS ≤ 2) and poor prognosis (mRS > 2).Results:In the regression analysis of prognostic influencing factors in patients with ACIS, it was concluded that an increase in daytime deep sleep time was associated with an increased possibility of adverse outcomes in patients with ACIS (OR = 1.026;) 95% CI, 1.003-1.048, P = 0.024). In the regression analysis of prognostic influencing factors in patients with PCIS, it was concluded that during PCIS, the duration of deep sleep was longer (OR = 1.038;) 95% CI, 1.001-1.077, P = 0.046) and the duration of nocturnal NREM staging was longer (OR = 1.010; Patients with 95% CI (1.000-1.020, P = 0.042) had a higher possibility of adverse outcomes.Conclusion: The sleep-wake state of patients with intracranial artery stenoischemic stroke changes. The main characteristics are increased diurnal sleep, increased incidence of daytime sleep, and disordered sleep-wake phases. In patients with ACIS, the diurnal sleep-wake biological rhythm mainly characterized by poor daytime stability is unbalanced. The longer the duration of daytime deep sleep and nighttime NREM sleep, the higher the possibility of adverse outcomes in patients with intracranial artery stenotic ischemic stroke.
Keywords: Intracranial arterial stenosis, ischemic stroke, Sleep-wake state, prognosis, prognostic factors analysis
Received: 13 Dec 2024; Accepted: 16 Jun 2025.
Copyright: © 2025 Zhang, Yuan, Xue, Fu, Ou, Zhao and Yan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Pingshu Zhang, Kailuan General Hospital, Tangshan, Hebei Province, China
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