ORIGINAL RESEARCH article
Front. Neurol.
Sec. Applied Neuroimaging
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1533853
This article is part of the Research TopicAdvanced fNIRS Applications in Neuroscience and Neurological DisordersView all 19 articles
A study on resting-state functional near-infrared spectroscopy in patients with different outcomes of prolonged disorders of consciousness
Provisionally accepted
- 1Jiangbin Hospital, Guangxi Zhuang Autonomous Region, Nanning, Guangxi Zhuang Region, China
- 2Yulin NO.1 People's hospital, Yulin, Shanxi Province, China
- 3University of Exeter, Exeter, England, United Kingdom
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Background: To explore the characteristics of resting-state functional connectivity in patients with different outcomes of prolonged disorders of consciousness(pDoC)by studying resting-state near-infrared imaging in patients with pDoC. Methods: 60 patients with pDoC were processed with resting-state near-infrared imaging and divided into unresponsive wakefulness syndrome/vegetative state (UWS/VS) group, minimally conscious state(MCS)group and escape minimally conscious state (EMCS) group according to the post-treatment state of consciousness, to analyze the difference of resting-state functional connectivity in patients with different outcomes of patients with pDoC. Results: Functional connectivity (FC) between frontal lobe and left occipital lobe, frontal lobe and right occipital lobe, and left and right occipital lobes decreased in the UWS/VS group compared with the MCS group; functional connectivity between frontal lobe and left occipital lobe, frontal lobe and right occipital lobe, and left and right occipital lobes decreased in the UWS/VS group compared with the EMCS group; functional connectivity did not show any significant difference between the EMCS and MCS groups; and functional connectivity was more centralized in the MCS group and EMCS group . Conclusion: Different outcomes of patients with pDoC have different degrees of decline in functional connectivity between frontal lobe and occipital lobe and between occipital lobe, resting-state functional near-infrared spectroscopy has a certain reference significance for the prognosis of patients with pDoC, and it is helpful for exploring the exploration of the conscious residual brain areas.
Keywords: resting-state, functional near-infrared spectroscopy, Prolonged Disorders of consciousness, outcomes, functional connectivity
Received: 25 Nov 2024; Accepted: 15 May 2025.
Copyright: © 2025 Liang, Liang, Li, Wang, Bi, 薛源 and Jiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Wenyu Jiang, Jiangbin Hospital, Guangxi Zhuang Autonomous Region, Nanning, Guangxi Zhuang Region, China
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