ORIGINAL RESEARCH article
Front. Neurol.
Sec. Neurological Biomarkers
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1538028
Analysis of the Correlation Between Peripheral Blood Inflammatory Markers and Imaging Burden of Cerebral Small Vessel Disease
Provisionally accepted
Jiayi Yang1,2
Hong Fang Li3*
Zhifeng Liang2Liying Mei2Jingru Wang2
Daojing Li3Liangchen Hu3
Rongrong Han3
Aimei Zhang3Liangliang Zhang4Chunxia Wang5- 1Department of Clinical Medicine, Jining Medical University,, 杨家怡, --请选择--, China
- 2School of Clinical Medicine, Jining Medical University, Jining, Shandong, China
- 3Department of Neurology, Affiliated Hospital of Jining Medical University, Jining, China
- 4Department of Hand and Foot Surgery, Affiliated Hospital of Jining Medical University, Jining, China
- 5Health Management Center, Affiliated Hospital of Jining Medical University, Jinan, Shandong Province, China
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The purpose of this study is to explore the relationship between peripheral blood inflammation-related indicators, such as neutrophil count (NC), neutrophil-to-lymphocyte ratio (NLR), and systemic immune-inflammation index (SII), and the imaging burden and subtypes of cerebral small vessel disease (CSVD). Methods ： Gather relevant indicators from the population who underwent physical examinations at the Affiliated Hospital of Jining Medical University between 2018 and 2023. Evaluate the total burden and various imaging markers according to the comprehensive burden score of cerebral small vessel disease (CSVD). Employ logistic regression analysis to investigate the correlation between neutrophil count (NC), neutrophil-to-lymphocyte ratio (NLR), and systemic immune-inflammation index (SII) with the overall burden of CSVD and its distinct markers. Results ： A cohort of 12,478 patients who underwent physical examinations was initially assembled. Following the application of specific inclusion and exclusion criteria, the study included 1,526 patients diagnosed with cerebral small vessel disease (CSVD) and 6,955 6,955 individuals serving as controls. Logistic regression analysis indicated no significant association between the overall burden scores of CSVD and systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NIR), or neutrophil count (NC). Nonetheless, within the spectrum of imaging markers for CSVD, a significant correlation was identified between deep microbleeds and SII (P=0.03), while enlarged perivascular spaces (EPVS) demonstrated a correlation with NC (P=0.029, P=0.019). Conclusion ：This analysis reveals a correlation between NC and SII with CSCD (especially Deep cerebral microbleeds and EPVS), which has warning implications for the prevention of CSVD.
Keywords: ：Cerebral small vessel disease, imaging, Inflammatory factors, Neutrophil count, Neutrophil-lymphocyte ratio, systemic immune-inflammation index
Received: 03 Dec 2024; Accepted: 25 Jun 2025.
Copyright: © 2025 Yang, Li, Liang, Mei, Wang, Li, Hu, Han, Zhang, Zhang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Hong Fang Li, Department of Neurology, Affiliated Hospital of Jining Medical University, Jining, China
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