ORIGINAL RESEARCH article
Front. Neurol.
Sec. Applied Neuroimaging
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1542292
Structural and Functional Disconnections in Non-Acute Post-Stroke Patients
Provisionally accepted
- 1Department of Rehabilitation Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China
- 2Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China
- 3Medical Imaging Center, Affiliated Cancer Hospital of Xinjiang Medical University, Urumqi, China
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Background: Structural alterations and functional reorganizations related to motor dysfunction after stroke remain unclear. This study aims to investigate alterations in structural connectivity (SC) and functional connectivity (FC) in non-acute post-stroke patients, and their associations with motor performance.Methods: Thirty-six non-acute post-stroke patients and thirty-eight well-matched healthy controls (HCs) were included. SC and FC differences between groups were analyzed using diffusion tensor imaging and resting-state fMRI, respectively.Correlations between SC and FC in regions with significant intergroup differences, along with their correlations with motor performance, were assessed.: Compared with HCs, significant decreases in both SC and FC were observed in stroke patients among the right precentral gyrus, right superior frontal gyrus, right supplementary motor area, right paracentral lobule, right middle cingulate gyrus, right superior marginal gyrus, right middle temporal gyrus, and left inferior temporal gyrus. A negative correlation of SC-FC was found between the right middle cingulate gyrus and right paracentral lobule in stroke group, while a positive correlation was found between the right superior marginal gyrus and right middle temporal gyrus. Moreover, the FC between the right superior marginal gyrus and right middle temporal gyrus showed negative correlations with the Fugl-Meyer assessment of the Upper/Lower Extremity scores.Discussion: This study identified disconnections in both SC and FC in sensorimotorrelated and high-order brain regions, which may enhance understanding of the structure-function interactions underlying motor deficits in post-stroke patients.
Keywords: stroke1, Motor dysfunctions2, magnetic resonance imaging3, Structural connectivity4, functional connectivity5
Received: 19 Dec 2024; Accepted: 02 Jun 2025.
Copyright: © 2025 Nan, Tian, Yu, Liu, Wu, Ming, Hong and Rong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jie Ming, Medical Imaging Center, Affiliated Cancer Hospital of Xinjiang Medical University, Urumqi, China
Wenjun Hong, Department of Rehabilitation Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China
Xu Rong, Department of Rehabilitation Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China
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