ORIGINAL RESEARCH article
Front. Neurol.
Sec. Movement Disorders
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1545126
This article is part of the Research TopicThe Exposome: Understanding Environmental Interactions in Tremor DisordersView all articles
Identifying key covariates of clinical outcomes for critically ill patients with Parkinson's disease: Analysis of the MIMIC-IV database
Provisionally accepted
- 1Department of Neurology, The Affiliated Hospital of Yunnan University, Kunming, China
- 2The First People’s Hospital of Yunnan Province, Kunming, Yunnan Province, China
- 3School of Clinical Medicine, Dali University, Dali, China
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Background: Parkinson's disease (PD) is a common chronic degenerative disease, and its exact pathological mechanism remains unclear. In this study, we identified covariates associated with the clinical outcomes of PD using patient data from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database, providing new references for the treatment of patients.Methods: The data of patients with PD and relevant covariates were obtained from the MIMIC-IV database. The patients were categorized into the in-hospital death and in-hospital survival groups based on their survival status, and the relationship between their outcomes and covariates was investigated.Key covariates markedly associated with the clinical outcomes of PD were further screened using regression analysis. Finally, a nomogram for predicting the risk of in-hospital mortality in patients with PD was constructed and validated.Results: A total of 143 patients with PD and 37 covariates were included in this study. Of the included patients, 25 were assigned to the in-hospital death group and 118 were assigned to the in-hospital survival group. Covariates such as the respiratory rate, mean arterial pressure (MAP), respiratory failure, anion gap, bicarbonate levels, blood urea nitrogen levels, and sequential organ failure assessment (SOFA) scores were markedly associated with in-hospital mortality in patients with PD.Subsequently, age (hazard ratio [HR] = 1.0565, 95% confidence interval [CI] = 1.0065-1.1090, p < 0.05), bicarbonate levels (HR = 0.8988, 95% CI = 0.8310-0.9722, p < 0.05), BUN levels (HR = 1.0292, 95% CI = 1.0084-1.0503, p < 0.05), and SOFA scores (HR = 1.1510, 95% CI = 1.0324-1.2831, p < 0.05) were identified as key covariates associated with in-hospital mortality. The nomogram incorporating these covariates exhibited favorable performance in predicting the risk of in-hospital mortality in patients with PD.Conclusion: This study revealed four key covariates associated with the clinical outcomes of PD, providing new references for the treatment of patients.
Keywords: Parkinson's disease, MIMIC IV database, Covariate, Nomogram， Prognostic factors， In-hospital mortality Parkinson's disease, MIMIC-IV database, nomogram, prognostic factors, Inhospital mortality
Received: 14 Dec 2024; Accepted: 23 Jun 2025.
Copyright: © 2025 Luo, Chen, Zhao, Dong and Long. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yuzhou Long, Department of Neurology, The Affiliated Hospital of Yunnan University, Kunming, China
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