ORIGINAL RESEARCH article
Front. Neurol.
Sec. Neuro-Otology
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1550568
This article is part of the Research TopicChallenges and Current Research Status of Vertigo/Vestibular Diseases Volume IIIView all 17 articles
Homocysteine, HHcy, H-type Hypertension and Dizziness: An NHANES Analysis
Provisionally accepted
- 1Xinjiang Medical University, Ürümqi, China
- 2Yuebei People's Hospital, Shaoguan, China
- 3College of Medicine, Shantou University, Shantou, Guangdong Province, China
- 4First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uyghur Region, China
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Background: Homocysteine (Hcy) is associated with various diseases, but its specific relationship with different types of dizziness remains unclear.Objectives: This study utilizes NHANES cross-sectional data to investigate the associations between Hcy levels, H-type hypertension, and various symptomatic dizziness, aiming to provide new insights for clinical diagnosis and treatment.This cross-sectional study analyzed 6,970 participants from NHANES (1999-2004) using weighted logistic regression, trend tests, restricted cubic spline analysis, and subgroup analysis.Results: Elevated Hcy levels and H-type hypertension showed significant positive associations with various symptomatic dizziness. HHcy showed the strongest association with fall risk (OR=1.83, 95% CI: 1.24-2.77), while H-type hypertension was most strongly associated with any symptomatic dizziness (OR=1.75, 95% CI: 1.34-2.28). No significant associations were found with positional dizziness. Trend analysis indicated a significant upward trend in the risk of any symptomatic dizziness, balance problems, and falling problems. RCS analysis demonstrated nonlinear relationships between Hcy levels and various symptomatic dizziness, including any symptomatic dizziness, balance problems, and falling problems.This study revealed that Hcy levels, HHcy, and H-type hypertension were significantly associated with various symptomatic dizziness. Recognizing and controlling HHcy and H-type hypertension are vital for dizziness management and diagnosis.
Keywords: Dizziness, Homocysteine, Hyperhomocysteinemia (HHcy), H-type hypertension, balance problems, Positional dizziness, Falling problems
Received: 23 Dec 2024; Accepted: 02 Jul 2025.
Copyright: © 2025 Liang, Lai and Feng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yiyin Liang, Xinjiang Medical University, Ürümqi, China
Juan Feng, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uyghur Region, China
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