REVIEW article
Front. Neurol.
Sec. Stroke
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1552848
Intrasaccular Therapy in Wide-neck Intracranial Aneurysms: A Narrative
Provisionally accepted
- 1Pengzhou People's Hospital, Pengzhou, Sichuan Province, China
- 2West China Hospital, Sichuan University, Chengdu, China
- 3West China School of Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China
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The treatment of wide-neck intracranial aneurysms (WNIAs) is a challenge in interventional therapy. Intrasaccular therapy, including intrasaccular flow disruption or formation of a neck bridge within the saccular, has been extensively used recently. The Medina ® Embolisation Device, Luna™ Aneurysm Embolisation System, Artisse™ Aneurysm Embolisation System, Contour Neurovascular System™, Neqstent™ Coil Assisted Flow Diverter, Woven EndoBridge (WEB) device, Nautilus™ Intrasaccular System, and Trenza Embolization Device™ have obtained Conformité Européene Mark certification. However, only WEB devices have been approved by the US Food and Drug Administration. The SEAL™ Endovascular Embolization System is approved for sale only in New Zealand. Angiographic resultspost-procedure and in the follow-up are the main indices used to measure the efficacy of intrasaccular therapy. Complications include ischaemia, thromboembolism, and related haemorrhage. This review summarizes and discusses the efficacy and safety of intrasaccular devices in treating WNIAs. Despite this, complete and satisfactory occlusions are accomplished in most cases of intrasaccular therapy for WNIAs, and the associated complications are typically regarded as acceptable. However, it is important to note that the occlusion rate with intrasaccular therapy is generally lower than that achieved through surgical clipping. Long-term follow-up of intrasaccular therapy and recurrence and retreatment of WNIAs is limited.
Keywords: Intracranial Aneurysm, wide-neck aneurysms, Endovascular procedure, Intrasaccular device, Interventional therapy
Received: 29 Dec 2024; Accepted: 11 Jun 2025.
Copyright: © 2025 Zhuo, Wu and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Changwei Zhang, West China School of Medicine, West China Hospital, Sichuan University, Chengdu, 610000, Sichuan Province, China
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