ORIGINAL RESEARCH article
Front. Neurol.
Sec. Stroke
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1555708
Analysis of risk factors for early neurological deterioration after intravenous thrombolysis in patients with acute ischemic stroke
Provisionally accepted
- Jiangsu University, Zhenjiang, China
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The aim of this study is to examine the potential risk factors contributing to early neurological deterioration (END) following intravenous thrombolysis in patients diagnosed with acute ischemic stroke (AIS). Methods: Clinical data was gathered from AIS patients who underwent intravenous thrombolysis at the Affiliated People's Hospital of Jiangsu University between January 2020 and December 2023. Patients were subsequently categorized into two groups based on the occurrence of END within 24 hours post-thrombolysis: the END group and the non-END group. A comparative analysis of the clinical data from both groups was conducted. The application of Multivariate Logistic regression facilitated the identification of independent risk factors and the construction of a nomogram prediction model. Results:The study encompassed a total of 249 AIS patients, with 32 patients (12.9%) developing END. The multivariate analysis revealed that NIHSS Score immediately after thrombolysis (P<0.001), the Trial of Org 10172 in Acute Stroke Treatment(TOAST)typing of large artery atherosclerosis (P=0.025), and a prior history of diabetes (P=0.023) were independent risk factors for the development of END post-thrombolysis. A nomogram was constructed to generate the ROC curve, and the AUC value was 0.809 (95% CI, 0.732-0.885). Conclusion: This nomogram, which demonstrates good discrimination and high predictive value, identifies NIHSS score immediately after thrombolysis, TOAST classification of large artery atherosclerosis, and a history of diabetes as independent risk factors for early neurological deterioration (END) in acute ischemic stroke (AIS) patients receiving intravenous thrombolysis.
Keywords: Acute ischemic stroke, intravenous thrombolysis, Early neurological deterioration, NIHSS score, TOAST
Received: 05 Jan 2025; Accepted: 21 Jul 2025.
Copyright: © 2025 Fang, Sun and Lu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xin-Yu Lu, Jiangsu University, Zhenjiang, China
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