ORIGINAL RESEARCH article
Front. Neurol.
Sec. Applied Neuroimaging
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1556822
This article is part of the Research TopicApplied Neuroimaging for the Diagnosis and Prognosis of Cerebrovascular DiseaseView all 10 articles
Grey-to-White Matter Ratio on Computer Tomography for Predicting Neurological Outcome in Patients with Heat Stroke: A Retrospective Cohort Study
Provisionally accepted
- 1Zunyi Medical University, Zunyi, Guizhou Province, China
- 2Chongqing Emergency Medical Center, Chongqing, China
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Objective: Grey-to-white matter ratio (GWR) is an early and sensitive indicator of cerebral oedema in patients with hypoxic-ischaemic brain injury, we aimed to evaluate the prognostic value of GWR for predicting neurological outcome in heat stroke patients. Methods: This multicentre retrospective analysis included 86 patients with heat stroke patients who underwent cranial computed tomography (CT). Patients were stratified by Cerebral Performance Category (CPC) scores at discharge: good outcome (CPC 1-2, n=65) versus poor outcome (CPC 3-5, n=21) in the derivation cohort. Seven GWR parameters were calculated from Hounsfield unit measurements at three different regions (basal ganglia, centrum semiovale, high convexity): putamen/corpus callosum (PU/CC), caudate nucleus/posterior limb of internal capsule (CN/PLIC), CN/CC, PU/PLIC, GWRbasal ganglia, GWRcerebrum, and GWRaverage. Prognostic performance of GWR was compared with qSOFA using receiver operating characteristic (ROC) analysis. And a validation cohort was used to verify the reliability. Results: All GWRs were significantly lower in the poor outcome group than in the good outcome group. ROC analysis showed the following areas under the curve:
Keywords: Heat Stroke, Grey-to-White Matter Ratio, Basal Ganglia, neurological outcome, computed tomgraphy (CT)
Received: 07 Jan 2025; Accepted: 18 Apr 2025.
Copyright: © 2025 Wei, Liu, Zhu, Yu, Luo, Zeng, Zhou and Duan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Fating Zhou, Chongqing Emergency Medical Center, Chongqing, China
Haizhen Duan, Zunyi Medical University, Zunyi, 563000, Guizhou Province, China
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