BRIEF RESEARCH REPORT article
Front. Neurol.
Sec. Neuro-Otology
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1558196
This article is part of the Research TopicNeuroinflammation, Neurodegeneration, and Auditory-Vestibular DisordersView all 16 articles
Anti-Neuroinflammatory Therapy for Non-Pulsatile Tinnitus in Patients with Sinus Vascular Anomalies: Preliminary Result on two cases
Provisionally accepted
- 1University of Campania Luigi Vanvitelli, Caserta, Campania, Italy
- 2Sapienza University of Rome, Rome, Lazio, Italy
- 3University of Rome Tor Vergata, Roma, Lazio, Italy
- 4Saint Camillus International University of Health and Medical Sciences, Rome, Lazio, Italy
- 5Michigan Medicine, University of Michigan, Ann Arbor, Michigan, United States
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Background: Vascular anomalies are commonly associated with pulsatile tinnitus, but their potential role in triggering non-pulsatile tinnitus through neuroinflammation is not well established.Furthermore, few studies have investigated non-pulsatile tinnitus associated with altered cerebrovascular supply and whether anti-neuroinflammatory therapy might alleviate symptoms.We describe two patients presenting with non-pulsatile tinnitus and sigmoid sinus stenosis confirmed by imaging, with other causes systematically excluded.Results: Magnetic resonance venography demonstrated severe stenosis of the transverse and sigmoid sinuses, alongside compensatory ipsilateral vascular dilatation. These structural abnormalities suggested disrupted venous blood flow, contributing to the neuroinflammatory processes associated with non-pulsatile tinnitus. Following treatment with an anti-inflammatory molecule, both patients reported a substantial reduction in tinnitus severity Conclusions: This study supports the potential of anti-inflammatory treatments in managing nonpulsatile tinnitus linked to sinus vascular anomalies. Further research is warranted to elucidate these relationships and confirm therapeutic efficacy of anti-inflammatory agents.
Keywords: Tinnitus, Neuroinflammation, Sigmoid sinus, hyperactive brain, palmythoylethanolamide, Luteolin (LUT)
Received: 09 Jan 2025; Accepted: 30 Jun 2025.
Copyright: © 2025 Di Stadio, MESSINEO, Indovina, Motta, Ralli and Brenner. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Arianna Di Stadio, University of Campania Luigi Vanvitelli, Caserta, 81100, Campania, Italy
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