Alterations in Frontotemporal Cerebral activity specific to auditory verbal hallucination during verbal fluency task in schizophrenia ：A fNIRS study

Jiaxin Zhang^1,2Ju Tian^3,4,5Jiuju Wang^3,4,5Huiting Qiao^1,2Wenxiang Quan^3,4,5Yanping Song^3,4,5Daifa Wang^1,2Wentian Dong^3,4,5,6*

• ¹Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beihang University, Beijing, Beijing Municipality, China
• ²School of Biological Science and Medical Engineering, Beihang University, Beijing, Beijing Municipality, China
• ³Peking University Sixth Hospital, Beijing, Beijing Municipality, China
• ⁴Institute of Mental Health, Peking University Sixth Hospital, Beijing, Beijing Municipality, China
• ⁵National Clinical Research Center for Mental Disorders, Peking University Sixth Hospital, Beijing, Beijing Municipality, China
• ⁶Beihang School, Beihang University, Beijing, China

Background: Patients with auditory verbal hallucination(AVH) may experience significant occupational and social functional disabilities, which bring a heavy burden to their families and society . Although neuroimaging studies have explored the brain regions associated with AVH and proposed models to explain AVH , the potential pathological mechanisms are not clear. Functional near-infrared spectroscopy (fNIRS) is a portable and suitable measurement, particularly in exploring brain activation during related tasks. Hence, our researchers aimed to explore the differences in the cerebral hemodynamic function between patients with schizophrenia with AVH (SZ-AVHs) and patients with schizophrenia without AVH(SZ-nAVHs) through fNIRS to examine neural abnormalities associated more specifically with AVH.Methods: A 52-channel functional near-infrared spectroscopy system was used to monitor hemodynamic changes in SZ-AVHs (n = 178) and SZ-nAVHs (n = 172) during a verbal fluency task (VFT). Clinical history, and symptom severity were also noted. The original fNIRS data were analyzed using NirSpark to obtain the brain functional eigenvalues including the integral value, which represents the degree of brain activation, and the centroid value, which represents the speed of blood oxygen response.Result: Our results showed that the integral values of the SZ-AVHs were significantly higher than those of the SZ-nAVHs in the left STC [t=3.16, p=0.014] while the centroid values of the SZ-AVHs were significantly higher than those of the SZ-nAVHs in the right vlPFC [t=2.78, p=0.046].Discussion: Our findings indicate that SZ-AVHs exhibited lower activation in the left STC and Slower response speed in the right vlPFC than SZ-nAVHs.