ORIGINAL RESEARCH article
Front. Neurol.
Sec. Endovascular and Interventional Neurology
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1561207
Potential correlation between dental caries and intracranial aneurysm: an innovative prognostic marker for intracranial aneurysm development
Provisionally accepted
- 1Department of the first clinical division, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin, China
- 2Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- 3Department of Interventional Neuroradiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China
- 4Beijing Tiantan Hospital, Capital Medical University, Beijing, Beijing Municipality, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
The prevalence of intracranial aneurysm (IA) in the population is approximately 3%-7%, with a rupture mortality rate as high as 40%. Identification of risk factors for IA occurrence and provision of targeted preventive and therapeutic measures are crucial for clinical diagnosis of IA. Dental caries is a common oral disease that affects the global population. In this study, we aimed to explore the potential connection between dental caries and the incidence of IA.We conducted a single-center retrospective 1:1 matched case-control study to assess the correlation between dental caries and the occurrence of IA among 230 participants.Participants were categorized into IA and non-IA groups. All participants underwent cerebral digital subtraction angiography or magnetic resonance angiography, as well as oral assessment.Using binary logistic regression analyses, we examined whether presence of dental caries was correlated with the occurrence of IA.Compared with the non-IA group, the IA group exhibited a greater prevalence of dental caries (90.44% vs. 56.52%) and a greater prevalence of history of root canal treatment (73.91% vs. 48.70%). Multiple logistic regression analysis revealed a significance between the presence of dental caries (OR: 4.14, 95% CI: 1.35-12.66) and IA occurrence. Also, the history of root canal treatment (OR: 2.03, 95% CI: 1.09-3.79) were significantly associated with IA occurrence (all p < 0.05).Dental caries was significantly associated with the incidence of IA. Cariogenic bacteria may enter the systemic circulation through pulp, potentially leading to pathological changes in normal cerebral blood vessels, such as the development of IA.
Keywords: Intracranial Aneurysm, Subarachnoid Hemorrhage, Dental Caries, Oral infection, Root canal treatment
Received: 15 Jan 2025; Accepted: 05 May 2025.
Copyright: © 2025 Sun, Gui, Wei, Jiang, Lin, Gong, Ge and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Huijian Ge, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, Beijing Municipality, China
Youxiang Li, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, Beijing Municipality, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.