BRIEF RESEARCH REPORT article
Front. Neurol.
Sec. Neurorehabilitation
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1561995
Exploring the Relationship Between Temperament Traits, Psychological Symptoms, and Functional Disability Assessed with the WHODAS 2.0 in Persons with Multiple Sclerosis
Provisionally accepted
Carmenrita Infortuna1Maria Buccafusca1Anita Maria Stella Graceffa1Enrica Maiorana1Ray Wang2Siddarth Ganesh3
Orion Yedidia3
Antonio Bruno1Fiammetta Iannuzzo1
Florian P Thomas3
Fortunato Battaglia3*- 1University of Messina, Messina, Sicilia, Italy
- 2Williams College, Williamstown, Massachusetts, United States
- 3Hackensack Meridian School of Medicine, Nutley, NJ, United States
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Background: The relationship between psychological comorbidity and functional impairment in multiple sclerosis (MS) remains to be thoroughly investigated. This study examined the associations between temperament traits, psychological comorbidities, and disability as measured by the World Health Organization Disability Assessment Schedule (WHODAS) 2.0 in persons with Relapsing-Remitting Multiple Sclerosis(RRMS)Methods: In this cross-sectional study, persons with RRMS underwent a comprehensive assessment of temperament profiles, psychological status, and functional disability. Assessment tools included the Depression Anxiety Stress Scale (DASS-21) and the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego Autoquestionnaire (TEMPS-A) short form. Functional status was evaluated using the 36-item WHODAS 2.0. Multivariate regression analyses were performed to evaluate relationships between variables.Results: The study cohort comprised 105 persons with RRMS Hierarchical regression models showed that age and disease duration were significant predictors, with age positively associated with D02 and D06 dimensions, and disease duration linked to D02 , D05, and D06 WHODAS 2.0 dimensions . Among temperament traits, hyperthymic temperament showed negative associations across multiple dimensions. Anxiety had strong positive association with disability . Model fit improved significantly with each step, with Step 3 explaining additional variance.Conclusions: These findings demonstrate significant associations between temperamental characteristics, particularly hyperthymic traits, -anxiety, and functional disability in persons with RRMS . Future research should investigate these relationships over time to understand causal links and create better treatments to slow disability progression. These findings could help improve how we assess and treat patients.
Keywords: Multiple Sclerosis, WHODAS 2.0, temperament traits, Anxiety, Depression, stress
Received: 17 Jan 2025; Accepted: 16 Jul 2025.
Copyright: © 2025 Infortuna, Buccafusca, Graceffa, Maiorana, Wang, Ganesh, Yedidia, Bruno, Iannuzzo, Thomas and Battaglia. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Fortunato Battaglia, Hackensack Meridian School of Medicine, Nutley, 07079, NJ, United States
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