ORIGINAL RESEARCH article
Front. Neurol.
Sec. Neurological Biomarkers
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1562361
The relationship between remote diffusion-weighted imaging lesions and Triglyceride-glucose index and clinical outcomes in patients with intracerebral hemorrhage
Provisionally accepted
- The First Affiliated Hospital of Kunming Medical University, Kunming, China
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The purpose of this study was to observe the relationship between the presence of distal diffusion-weighted imaging (DWI) lesions and triglyceride-glucose (TyG) index and clinical outcome after intracerebral hemorrhage (ICH), and identify the risk factors for DWI lesions in ICH patients.University were retrospectively collected. Demographic data, laboratory examination, and imaging data of the patients were collected. The patients were divided into two groups based on the presence or absence of distal DWI lesions as determined by magnetic resonance imaging (MRI). Multivariate logistic regression analysis was used to evaluate the risk factors for DWI lesions and clinical outcome.Results: Among 245 ICH patients included in this study, 46(18.78%) had DWI lesions and 199 (81.22%) did not. We found the occurrence probability of DWI lesions reached the maximum in the range Q2 of TyG index. ICH patients with DWI lesions had a similar frequency of death or disability at 90 days compared with patients without DWI lesions. Multivariate logistic regression analysis showed that high fasting glucose (P=0.039) and hematoma site (P=0.048) were significant predictors for DWI lesions after ICH. The old age (P<0.001), higher NIHSS score (P<0.001), and midline shift (P=0.034) were independent predictor of poor functional outcome at 3 months.There was no a definitive correlation between the TyG index and distal DWI lesions in our study. The elevated high fasting glucose levels and hematoma site were significant predictors for DWI lesions after ICH.
Keywords: intracerebral hemorrhage, DWI lesions, Triglyceride-glucose index, clinical outcome, Insulin Resistance
Received: 25 Feb 2025; Accepted: 03 Jul 2025.
Copyright: © 2025 Wang, Gu, Lei, Zhang, Jiang, Yang, Jin and Deng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Chunyan Lei, The First Affiliated Hospital of Kunming Medical University, Kunming, China
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