ORIGINAL RESEARCH article
Front. Neurol.
Sec. Neurological Biomarkers
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1567158
Associations of serum neurofilament and asthma: Evidence from the NHANES 2013-2014
Provisionally accepted
- Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Jiangsu Province, China
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Background: Neural mechanisms are important in asthma, and serum neurofilament light chain (sNfL) is a biomarker of neuronal damage. This study investigated the correlation between sNfL and asthma.This cross-sectional study was based on NHANES data and used multiple logistic regression analysis, subgroup analysis, and smoothed curve fitting to explore the relationship between sNfL and asthma. Covariate selection was validated using the variance inflation factor (VIF).The study involved 1773 participants. Results showed that Ln-sNfL (OR=1.39, 95% CI: 1.03-1.88, p=0.0325) was positively associated with asthma. Subgroup analyses showed that age, gender, race, education level, marital status, family income, BMI, alcohol use, smoking, diabetes, hypertension and PAMs did not affect the positive association between sNfL and asthma (p>0.05) (FDR corrected p>0.1). E-value analysis suggested robustness to unmeasured confounding.There is a positive correlation between sNFL and asthma, and further large-scale and prospective studies are needed to replicate our results and assess the ability of sNfL to predict asthma.OR, odds ratio; Cl, confidence interval; Family income, the ratio of family income to poverty; BMI, 503 body mass index; PAMs, prophylactic asthma medications. 504
Keywords: Asthma, Serum neurofilament (sNfL), biomarker, Neural mechanism, NHANES
Received: 26 Jan 2025; Accepted: 23 Jun 2025.
Copyright: © 2025 Yang, Qian, Zhu and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Qiong Xu, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Jiangsu Province, China
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