SYSTEMATIC REVIEW article
Front. Neurol.
Sec. Neurorehabilitation
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1567482
This article is part of the Research TopicAdvancing Neurosonology: Integrating Ultrasound Applications and Artificial Intelligence in NeurologyView all articles
Transcranial Ultrasound Stimulation Parameters for Neurological Diseases: A Systematic Review
Provisionally accepted
- 1Beijing Rehabilitation Hospital, Capital Medical University, Beijing, China
- 2Department of Rehabilitation Radiology, Beijing Rehabilitation Hospital, Capital Medical University, Beijing, Beijing Municipality, China
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Background: Transcranial ultrasound stimulation (TUS) is a non-invasive neuromodulation technique with promising clinical potential. Its therapeutic efficacy and safety are significantly influenced by stimulation parameters. This study investigates how various stimulation parameters modulate human brain function, offering insights for optimizing stimulation protocols to improve clinical and research outcomes. Methods: A comprehensive literature search was conducted across the Medline-PubMed, Web of Science, Medline-Ovid, Embase, EBSCOhost, Cochrane Library, CNKI, WanFang, and VIP databases using the keyword "transcranial ultrasound stimulation," covering publications up to September 24, 2024. Two researchers independently screened articles according to predefined inclusion and exclusion criteria. Extracted data included article details, demographic information, interventions, study design, data analysis, and results. The risk of bias was assessed using the RoB2 and ROBINS-I tools. Multiple linear regression analysis explored the relationship between TUS parameters and human physiological responses. Results: Thirty-five studies were included, consisting of 10 randomized controlled trials and 25 other studies, involving 664 participants (over 34% female) aged 10 to 90 years. Eighteen studies used focused transcranial ultrasound (fTUS), six used non-focused TUS (no-fTUS), and 11 used transcranial pulse stimulation (TPS). Fundamental frequencies ranged from 220 to 650 kHz, and spatial peak pulse average intensities (ISPPA) ranged from 0.5 to 31 W/cm². Frequency, pulse repetition frequency, and mechanical index showed significant effects (𝑝 < 0.05). Conclusion: TUS demonstrates disease-specific therapeutic potential, with low-frequency protocols targeting neurodegenerative disorders and high-frequency parameters effectively alleviating motor symptoms. Core parameters (fundamental frequency, pulse repetition frequency, mechanical index) modulate neuroplasticity-driven outcomes, accompanied by mild transient adverse effects (incidence<5%). Large-scale randomized trials integrating multimodal navigation are required to standardize dose-response frameworks and refine spatial targeting for clinical translation.
Keywords: Physiotherapy, Rehabilitation, non-invasive neuromodulation, Transcranial ultrasound stimulation, Neurological Diseases
Received: 30 Jan 2025; Accepted: 30 Apr 2025.
Copyright: © 2025 Wang, Wang, Jiang, Wang, Li and Qie. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Shuyan Qie, Department of Rehabilitation Radiology, Beijing Rehabilitation Hospital, Capital Medical University, Beijing, 100144, Beijing Municipality, China
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