ORIGINAL RESEARCH article
Front. Neurol.
Sec. Neurorehabilitation
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1572650
This article is part of the Research TopicUnlocking Potential: Cognitive Rehabilitation for Individuals with Acquired Brain InjuriesView all 6 articles
Handgrip strength is associated with cognitive function in patients with head injury with loss of consciousness: results from the NHANES 2011-2014
Provisionally accepted
- 1First Affiliated Hospital of Fujian Medical University, Fuzhou, China
- 2Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou Province, China
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We evaluated the relationship between handgrip strength (HGS) and cognitive function in patients with head injury with loss of consciousness (HIC) using National Health and Nutrition Examination Survey (NHANES) data.: Utilizing the 2011-2014 NHANES database, we screened participants who completed the HIC questionnaire and extracted relevant variables. Key variable was the sum of maximum bilateral HGS. Cognitive function encompassed global cognitive function, Immediate Recall Test (IRT), Delayed Recall Test (DRT), Animal Fluency Test (AFT), and Digit Symbol Substitution Test (DSST). Weighted multivariate linear regression analyzed the relationship. Gender-stratified analyses explored differences. Restricted cubic spline models elucidated the dose-response curves of HGS on cognitive function. Results: Among 283 American HIC patients, HGS significantly correlated positively with global cognitive function, IRT, DRT, and DSST. Gender-stratified analysis showed that HGS enhancement significantly improved DRT and DSST scores in males, while females primarily benefited in Global cognitive function and AFT. Restricted cubic spline analysis confirmed a consistent linear dose-response relationship between HGS and cognitive function indicators, valid in both genders.Our study reveals a positive correlation between HGS and cognitive function in HIC patients, with gender differences, offering a novel perspective for cognitive status assessment. Future large-scale, multidimensional studies are needed to deepen understanding of the complex HGS-cognitive function relationship.
Keywords: Head injury with loss of consciousness, handgrip strength, Cognitive Function, gender, NHANES
Received: 07 Feb 2025; Accepted: 24 Jun 2025.
Copyright: © 2025 Guo, He, Zeng, Xu and Yan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xiang Xu, First Affiliated Hospital of Fujian Medical University, Fuzhou, China
Zhipeng Yan, First Affiliated Hospital of Fujian Medical University, Fuzhou, China
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