ORIGINAL RESEARCH article
Front. Neurol.
Sec. Neurological Biomarkers
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1573027
This article is part of the Research TopicGenetic Insights and Diagnostic Innovations in Cerebrovascular and Cerebrospinal Fluid DisordersView all 8 articles
The association between Serum Klotho protein and Stroke ：a cross-sectional study from NHANES 2007-2016
Provisionally accepted
- Department of Neurology, The Second Hospital of Shandong University, Jinan, China
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Objective: Serum Klotho protein is a protein with anti-aging effects. Since the relationship between serum Klotho and Stroke remains rather ambiguous, this research probed into the potential correlation between serum Klotho concentration and Stroke. Methods: This study employed a cross-sectional design and incorporated population data from the NHANES from 2007 to 2016. Weighted univariate and multivariate logistic regression models were utilized to inspect the relationship between Klotho and Stroke. Stratified analyses and interaction tests were carried out to explore the latent correlation between Klotho and Stroke. Finally, a fitted smooth curve was adopted to depict the non-linear relationship. Results: In this study, after excluding all the missing data, a total of 12414 participants were encompassed, including 450 Stroke individuals. After adjusting for all covariates, higher Klotho was associated with a lower prevalence of Stroke. According to the subgroup analyses and interaction tests, age, gender, race, BMI, hypertension, diabetes mellitus, family members, drinker and smoker were not significantly correlated with the influence of Klotho and Stroke. After adjusting for all covariates, higher Klotho was associated with a lower prevalence of stroke [OR: 0.68, 95% CI: 0.47 -0.99].This study disclosed the negative correlation between serum Klotho protein levels and the prevalence of Stroke. Further prospective studies are requisite to investigate the impact of serum Klotho protein levels on Stroke and determine the causal relationship.Stroke represents the second leading global cause of mortality, surpassed only by acute ischemic heart disease (Feigin et al., 2022). This dsevere acute cerebrovascular disease 1 Hongjia Xu and Yiming Ding contributed equally to this article.
Keywords: ：Klotho, Stroke, Atherosclerosis, Cross-sectional study, NHANES
Received: 11 Feb 2025; Accepted: 25 Apr 2025.
Copyright: © 2025 Xu, Zhang, Li, Zhou, Wang, Xing, Ma, Wang and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Cunfu Wang, Department of Neurology, The Second Hospital of Shandong University, Jinan, China
Shunliang Xu, Department of Neurology, The Second Hospital of Shandong University, Jinan, China
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