REVIEW article
Front. Neurol.
Sec. Neurotrauma
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1573779
Spinal cord injury modeling: from modeling to evaluation using rats as examples
Provisionally accepted
- 1Department of Spine Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China
- 2Department of Spine Surgery, Second Xiangya Hospital, Central South University, Changsha, Anhui Province, China
- 3Department of orthopedic, Affiliated hospital, Jiujiang University, Jiujiang, Hebei Province, China
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Spinal cord injury(SCI), with its enormous impact on individuals and society, seriously affects patients' quality of life and is the focus and challenge of current medical research. The selection of appropriate SCI models and the reduction of heterogeneity between models are crucial for basic research on SCI. Although many articles have summarized and compared various SCI models, there are limited descriptions of how to further select the model animals after selecting the type of model, the degree of SCI, the use of anesthesia and analgesia, experience with modeling techniques, preoperative and postoperative care, management of common complications, sample collection, and evaluation of the spinal cord after injury. This paper aims to provide a practical guide for researchers who need to construct SCI models by combining the experimental experience of our research team in modeling and other related research literature. These guidelines will promote the standardization of SCI models, thus providing a solid foundation for in-depth research on SCI and the development of therapeutic strategies.
Keywords: spinal cord injury, Animal Models, Contusion Models, Behavioral assessment, Pathophysiological processes
Received: 09 Feb 2025; Accepted: 30 May 2025.
Copyright: © 2025 Wang, Cai, Zhu, Zeng, Hu and Shi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Benchao Shi, Department of Spine Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China
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