ORIGINAL RESEARCH article
Front. Neurol.
Sec. Endovascular and Interventional Neurology
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1584983
This article is part of the Research TopicInnovation Application and Outcomes in Flow Diverter Interventions for Complex Intracranial AneurysmsView all articles
Tubridge flow-diverting stent for treatment of unruptured intracranial complex aneurysms
Provisionally accepted
- The Second Affiliated Hospital of Kunming Medical University, Kunming, China
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To investigate the efficacy and safety of the Tubridge flow diverter (TFD) in treating unruptured intracranial complex aneurysms. Methods A retrospectively was performed on consecutive patients with unruptured intracranial complex aneurysms treated with TFD at our institution between October 2019 and December 2022. Clinical data, including demographic characteristics, angiographic findings, and follow-up outcomes, were collected to assess postoperative and follow-up aneurysm occlusion rates. Complications and clinical outcomes were evaluated, with favorable outcomes defined as a modified Rankin Scale (mRS) score of 0-2. Results A total of 72 patients harboring 75 aneurysms were included, with 47 aneurysms treated with TFD alone and 28 undergoing combined TFD and coiling. Fifty-six aneurysms in 53 patients underwent at least one digital subtraction angiography (DSA) examination. The median follow-up duration at the final visit was 156.00 days, yielding a successful aneurysm occlusion rate of 78.57% (44/56) and a median time to occlusion of 139.00 days. The complete occlusion rate was significantly higher in non-saccular aneurysms (92.86%, 13/14) than in saccular aneurysms (64.29%, 27/42). Severe stenosis (>50%) occurred in 3 of 55 stents (5.45%). Among 67 patients (5 lost to follow-up), 4 ischemic and 8 hemorrhagic complications were recorded, with 97.01% of patients achieving an mRS score of 0-1.. Conclusion Small-to-medium-sized aneurysms (maximum diameter <10 mm) can be effectively managed with TFD alone. TFD demonstrates minimal impact on branch vessels, and patients with mild in-stent stenosis may be monitored without intervention. The TFD is safe and effective for treating various types of unruptured intracranial complex aneurysms.
Keywords: Intracranial Aneurysm, Tubridge flow diverter, complex intracranial aneurysms, brain disease, flow diversion
Received: 28 Feb 2025; Accepted: 09 May 2025.
Copyright: © 2025 Juan, Zhang and Cao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yi Cao, The Second Affiliated Hospital of Kunming Medical University, Kunming, China
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