ORIGINAL RESEARCH article
Front. Neurol.
Sec. Movement Disorders
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1586749
This article is part of the Research TopicClinical and Neurophysiological Features of Progressive Supranuclear Palsy and Other Parkinsonism SyndromesView all 3 articles
Fatigue in patients with Parkinson's disease and its associated and predictive factors
Provisionally accepted
- 1The Fourth Hospital of Baotou, Baotou, China
- 2Affiliated Hospital of Jining Medical University, Jining, Shandong Province, China
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The purpose of this study is to ascertain the incidence of fatigue and to determine the predictive and related variables of fatigue in patients with Parkinson's disease (PD). METHODS: A sample of 130 healthy individuals (39.23% male, mean age 64.19 ± 8.70 years) and 130 patients with PD (50.00% males, mean age 65.06 ± 9.04) were enrolled in the study. All participants were evaluated using the Fatigue Severity Scale (FSS), Mini-Mental State Examination (MMSE), Hamilton anxiety scale (HAMA), and Hamilton depression scale (HAMD). Patients with PD were assessed with the Unified Parkinson's Disease Rating Scale (UPDRS), Hoehn & Yahr staging, the MMSE, HAMA, HAMD, the Parkinson`s Disease Sleep scale-2 (PDSS-2), and Parkinson`s Disease Questionnaire-39 (PDQ-39).1. The PD group exhibited significantly higher scores in the FSS (P ＜ .001) and demonstrated a greater susceptibility to fatigue compared to the control group.2. The FSS score in female patients was significantly higher than that in male patients (P =.003).3. Patients experiencing fatigue exhibited significantly higher scores on the UPDRS (P < .001), Hoehn & Yahr staging (P < .001), NMSS (P < .001), HAMD (P < .001), HAMA (P < .001), PDSS-2 (P = 0.012), and PDQ-39 (P < .001) compared to those without fatigue.NMSS, HAMD, HAMA, PDSS, PDQ-39, UPDRS III, and the Hoehn & Yahr staging. Further multiple linear regression analysis indicated that the NMSS score, depression score, and PDQ-39 score were significantly associated with fatigue. Receiver Operating Characteristic (ROC) curves demonstrated that HAMD, with a cut-off value 4.50, effectively detected fatigue, yielding a sensitivity of 0.690 and a specificity of 0.669. 5. CONCLUSION: Patients with Parkinson's disease experience a higher incidence of distressing fatigue compared to healthy individuals. The significant prevalence of fatigue among these patients is linked to various motor and non-motor symptoms.
Keywords: Parkinson's disease, Fatigue, Associated factors, Motor symptoms, non-motor symptoms
Received: 03 Mar 2025; Accepted: 30 Jun 2025.
Copyright: © 2025 Ning†, Lu, Guo†, Wang, Sun and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yaning Lu, The Fourth Hospital of Baotou, Baotou, China
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