HHypertension mediates the association between weight-adjusted waist index and new onset stroke risk in middle-aged and older Chinese adults: Evidence from the CHARLS study

Fei Xu¹Hongwei Liu¹Meng Li¹Minheng Zhang²Xuan Chen¹Miao miao Hou^3*

• ¹Taiyuan Central Hospital, Taiyuan, China
• ²First People’s Hospital of Jinzhong, Jinzhong, Shanxi Province, China
• ³Shanxi Bethune Hospital, Shanxi Medical University, Taiyuan, Shanxi Province, China

The weight-adjusted waist index (WWI) serves as a novel body metric for evaluating abdominal adiposity. However, the association between WWI and stroke risk across varying blood pressure statuses remains poorly understood.Methods: This study included 12,580 individuals aged 45 and above with no prior stroke incidents, drawn from the China Health and Retirement Longitudinal Study (CHARLS) between 2011 and 2020. Multiple analytical approaches were utilized to assess the relationship linking WWI and incident stroke, including Cox proportional hazards regression, restricted cubic splines, subgroup analyses, and sensitivity analyses. The predictive capacity of WWI for stroke was evaluated through receiver operating characteristic (ROC) curves, with further stratification based on blood pressure status and other anthropometric indicators. A mediation approach was employed to investigate the intermediary role of hypertension in the WWI-stroke association.The investigation recruited 12,580 participants, 727 (5.78%) experienced stroke events. Across all Cox regression models, increased WWI consistently demonstrated a significant association with elevated stroke risk (HR=1.12, 95%CI: 1.02-1.22, p=0.012), particularly in individuals with pre-hypertension (HR=1.20, 95% CI: 1.00-1.46, p=0.044) and hypertension (HR=1.13, 95% CI: 1.01-1.25, p=0.032). Additional sensitivity examinations further corroborated the consistency of our results regarding WWI's predictive accuracy for stroke risk. The ROC curves revealed that WWI exhibited the highest predictive accuracy for stroke risk (AUC=0.679) among the anthropometric indices evaluated, outperforming other conventional indicators. The predictive performance was significantly stronger in the hypertension group (AUC=0.672) than in different subgroups. Mediation effect analysis indicated that hypertension partially mediated the impact of WWI on stroke (β: 0.015, p<0.001), accounting for 12% of WWI's total effect on stroke incidence.This study revealed that elevated WWI levels independently contribute to a higher stroke occurrence rate in middle-aged and older adult demographics, with a particularly pronounced effect observed in hypertensive individuals.