SYSTEMATIC REVIEW article
Front. Neurol.
Sec. Experimental Therapeutics
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1588535
Therapeutic role of mesenchymal stem cells in neurogenesis for management of neurological disorders: A Scientometric study to an indepth review
Provisionally accepted
- 1Zhejiang Chinese Medical University, Hangzhou, China
- 2Quzhou City People's Hospital, Quzhou, China
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The biological process of neurogenesis involves the production of new and completely functional neurons in two specific regions of the brain: the ventricularsubventricular zone (V-SVZ) and the subgranular zone (SGZ) of the hippocampal dentate gyrus by neural stem cells (NSCs). Interfering with this mechanism harms the brain and may result in neurological disorders. Cell-based therapies are becoming recognized as optimal possibilities for facilitating neurogenesis. To comprehend the many processes and mechanisms of neurogenesis and the role of mesenchymal stem cells (MSCs) as active contributors to pathologic events influencing neurogenesis. We utilized the Web of Science (core collection) as the data source. The search was performed in the Web of Science core collection database until April 30, 2024, with the terms "Mesenchymal stem cells" as the title and "neurogenesis" as the topic. A total of 407 papers about mesenchymal stem cells in neurogenesis published from 2004 to 2024 were retrieved. Further, we performed a bibliometric analysis of these publications, such as generating cooperation maps, co-citation analysis of journals and references, and cluster analysis of keywords. Next, we discussed the mechanism by which MSCs promote neurogenesis during the onset of Alzheimer's disease (AD) and stroke diseases. Overall, three aspects primarily reflect the treatment of stroke with MSCs: neural circuit reconstruction, mitochondrial transfer, and extracellular vesicle transfer. The treatment of AD with MSCs is mainly reflected in the five aspects of inhibiting neuroinflammation, microglia changes, amyloid-β removal, functional recovery of autophagy, and blood-brain barrier (BBB) function recovery. Finally, we also made prospects for future research of MSCs.
Keywords: Neurogenesis, Stroke, Alzheimer's disease, Mesenchymal stem cells, Scientometric Abbreviations: MSCs, Mesenchymal stem cells, AD, Alzheimer's disease, NSCs, neural stem cells, V-SVZ, ventricular-subventricular zone, HD, Huntington's disease, PD, Parkinson's disease, OGD/R, Oxygen glucose deprivation and reoxygenation, TNTs, Tunnel nanotubes
Received: 25 Mar 2025; Accepted: 29 May 2025.
Copyright: © 2025 Wang, Jiang, Feng, Li, Chu and Fang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Qian Wang, Zhejiang Chinese Medical University, Hangzhou, China
Lisheng Chu, Zhejiang Chinese Medical University, Hangzhou, China
Yan Fang, Zhejiang Chinese Medical University, Hangzhou, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.