ORIGINAL RESEARCH article
Front. Neurol.
Sec. Endovascular and Interventional Neurology
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1588875
Low Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) Score Increases Symptomatic Intracranial Hemorrhage Risk in Thrombectomy Patients
Provisionally accepted
- Nanjing Medical University, Nanjing, China
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The HALP index, a composite biomarker integrating hemoglobin, albumin, lymphocyte, and platelet parameters, reflects both immunological competence and nutritional status. We therefore conducted this retrospective analysis to assess the correlation between HALP score and the risk symptomatic intracranial hemorrhage (sICH) risk in patients receiving mechanical thrombectomy (MT).Methods: This retrospective study included patients with acute ischemic stroke due to anterior circulation large vessel occlusion who underwent MT between October 2019 and July 2024. The HALP index was calculated based on admission laboratory parameters. The sICH was diagnosed according to Heidelberg Bleeding Classification criteria within 72 hours post-procedure. Multivariate logistic regression analysis was performed to identify independent association between pretreatment HALP score and sICH risk after adjusting for covariates.Results: A total of 735 patients (mean age, 71.3 ± 10.9 years; 423 male) were enrolled in this study. sICH was diagnosed in 82 patients (11.2%) during hospitalization. After adjusting for demographic characteristics and other covariates, multivariate logistic regression analysis revealed that a low HALP index was significantly associated with an elevated risk of sICH (odds ratio: 1.058, 95% confidence interval: 1.024-1.094, P=0.001). findings were obtained when the HALP score was analyzed as a categorical variable. Additionally, the restricted cubic spline analysis confirmed a linear inverse relationship between the HALP index and the risk of sICH following MT (P=0.551 for non-linearity).Our data confirmed a significant inverse correlation between the HALP score and the sICH risk in patients treated with MT. This suggests that the HALP score may serve as a valuable tool for monitoring and managing sICH risk in ischemic stroke patients following reperfusion therapy.
Keywords: HALP index, large vascular occlusive stroke, Symptomatic intracranial hemorrhage, Mechanical thrombectomy, predictor
Received: 06 Mar 2025; Accepted: 14 Jul 2025.
Copyright: © 2025 Chen, Huang, Qi, Bin, E, Zhang and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xiaohao Zhang, Nanjing Medical University, Nanjing, China
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