SYSTEMATIC REVIEW article
Front. Neurol.
Sec. Movement Disorders
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1589842
Dopamine in Tourette Syndrome: A 30-Year Bibliometric Analysis of Hotspot evolution
Provisionally accepted
- 1Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China
- 2Nanjing Gaochun Traditional Chinese Medicine Hospital, Nanjing, China
- 3Suqian Hospital , Affiliated to Nanjing University of Chinese Medicine, Suqian, Jiangsu Province, China
- 4Jiangyin Hospital of Traditional Chinese Medicine, Jiangyin, China
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Tourette Syndrome (TS), a neurodevelopmental disorder, requires attention to the physical and psychological impacts of tics and associated comorbidities. Researchers are making efforts to clarify the pathophysiology of TS and develop effective treatments amidst its rising global prevalence. This study aimed to retrieve publications discussing TS in the context of the dopaminergic system from 1994 to 2023, summarize previous research, and analyze the general information and hotspots to provide references for future research and clinical applications. Literature was filtered from the Web of Science Core Collection. Excel, CiteSpace, VOSviewer, and Scimago Graphica were used to analyze and visualize the results. A total of 482 related publications were included in the study. The United States has consistently led in research output, and Yale University demonstrates excellence in workload, impact, and collaboration. Harvey S. Singer has the highest number of publications. The hotspots include comorbidities, dopaminergic Components, candidate genes, and deep brain stimulation. The analysis reveals that the understanding of TS is gradually evolving towards neuronal and genetic mechanisms. Concurrently, deep brain stimulation is being investigated as a treatment for refractory TS. These findings suggest a need for more in-depth research to produce higher-level evidence.
Keywords: Tourette Syndrome, Dopamine, Bibliometric, visual analysis, hotspots
Received: 08 Mar 2025; Accepted: 31 Aug 2025.
Copyright: © 2025 Liu, Luo, Zhu, Ding, Wang, Zhao and Yuan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Bin Yuan, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China
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