ORIGINAL RESEARCH article
Front. Neurol.
Sec. Neurological Biomarkers
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1590408
Association Between Serum Uric Acid Levels and White Matter Hyperintensities in Patients With Mild Ischemic Stroke
Provisionally accepted
Chaoxin Chai1,2,3
Yuqi Cui1,2,3Meng Li1,2,3Jianing Xia1,2,3Yiming Wang1,2,3Fuyun Ren1,2,3Liping Chen1,2,3*- 1Key Laboratory of Clinical Neurology (Hebei Medical University), Ministry of Education, Shijiazhuang, Hebei, China, Shijiazhuang, Hebei Province, China
- 2Department of Neurology, the Second Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, China，, Shijiazhuang, China
- 3Key Neurological Laboratory of Hebei Province, Shijiazhuang,050000， Hebei, China, Shijiazhuang, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Objective: This study aims to investigate the association between uric acid (SUA) level and white matter hyperintensities (WMH) in patients with mild ischemic stroke. Methods and Results : This study retrospectively analyzed 290 patients with mild ischemic Stroke who were hospitalized at the Second Hospital of Hebei Medical University from March 2021 to January 2022. General clinical information and laboratory test results were collected. WMH was interpreted on MRI, and periventricular hyperintensity (PVH) and deep white matter hyperintensities (DWMH) were scored respectively. According to the score of Fazekas , WMH was divided into two groups. Factors influencing WMH severity were analyzed, and the relationship between SUA and WMH was further explored.The results showed that the SUA of patients with moderate to severe DWMH was higher than that of patients with no or mild DWMH (345.10±97.52umol/L vs. 317.99±91.21umol/L, P=0.028). There was no significant difference in SUA between the moderate to severe PVH group and the no or mild PVH group (336.49±99.29umol/L vs. 319.16±89.92umol/L, P=0.131). Spearman correlation analysis showed that SUA was positively correlated with the severity of DWMH (r=0.123, P=0.037), while SUA was not significantly correlated with PVH severity (r=0.070, P=0.234). After adjusting for confounders by multifactor logistic regression, SUA was independently correlated with DWMH severity (OR: 1.005, 95%CI: 1.002-1.009, P=0.004). There was no significant correlation between SUA and PVH ((OR: 1.003, 95%CI: 1.000-1.006, P=0.051). Conclusion: SUA is an independent risk factor for DWMH in patients, and there is no significant correlation between SUA level and PVH.
Keywords: Serum uric acid, Mild ischemic stroke, White matter hypersignaling, Periventricular hyperintensity (PVH), Deep white matter hyperintensities
Received: 08 Apr 2025; Accepted: 07 Jul 2025.
Copyright: © 2025 Chai, Cui, Li, Xia, Wang, Ren and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Liping Chen, Department of Neurology, the Second Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, China，, Shijiazhuang, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.