ORIGINAL RESEARCH article
Front. Neurol.
Sec. Endovascular and Interventional Neurology
Volume 16 - 2025 | doi: 10.3389/fneur.2025.1595054
Endovascular therapy and Medical Management of Large-Core Infarcts: Prognostic Determinants in a Retrospective Cohort
Provisionally accepted
- 1School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China
- 2Department of Neurology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China
- 3School of Clinical Medicine, Southwest Medical University, Luzhou, China
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To investigate the independent prognostic risk factors in acute ischemic stroke patients with large-core infarcts, including patients beyond standard eligibility thresholds for core volume or ASPECTS and provide evidence for early clinical intervention.This retrospective cohort study analyzed the clinical data of 96 consecutive patients with large-core infarcts admitted to a regional stroke center between June 2020 and June 2024. Participants were stratified into poor outcome (modified Rankin Scale [mRS] 4-6) and favorable outcome (mRS 0-3) groups based on the 90-day post-intervention assessments. Comparative analyses of the baseline demographics, biochemical parameters, neuroimaging metrics, and treatment modalities were conducted. Univariate analysis followed by multivariate logistic regression was used to identify independent predictors of favorable outcome. A prespecified EVT subgroup analysis was performed, including procedural variables (onset-to-puncture time, puncture-to-recanalization time) and clinical variables in multivariate regression.Results: Among the 96 patients, 17 (17.7%) achieved favorable outcomes (mRS 0-3) and 79 (82.3%) had poor outcomes (mRS 4-6). Multivariable analysis identified four independent predictors of poor outcome: non-receipt of EVT (OR =10.22, 95% confidence Interval [CI]: 1.05-99.76), hyperglycemia (per 1 mmol/L; OR = 1.76, 95% CI: 1.10-2.82), and higher platelet count (per 10³/μl; OR = 1.02, 95% CI: 1.00-1.03) (all P < 0.05). In the EVT subgroup (n = 62), hyperglycemia remained significantly associated with poor outcomes (OR = 1.70, 95% CI: 1.04-2.78, P = 0.034).EVT significantly improves functional outcomes in large-core infarcts. Preoperative hyperglycemia and elevated platelet count are independent predictors of poor outcomes. These findings support standardized protocols that integrate early EVT with glycemic control and coagulation monitoring in this patient population.
Keywords: Endovascular Therapy, Large-Core Infarcts, prognostic determinants, Hyperglycemia, Thrombocytosis
Received: 18 Mar 2025; Accepted: 14 May 2025.
Copyright: © 2025 Li, Tao, Liu, Fan, Zhong, Huang, Yu and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Neng-Wei Yu, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610054, Sichuan Province, China
Bing-Hu Li, Department of Neurology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China
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